4-Ethylquinoline

Base Information

• Chemical Name: 4-Ethylquinoline
• CAS No.: 19020-26-9
• Molecular Formula: C11H11N
• Molecular Weight: 157.215
• Hs Code.: 2933499090
• European Community (EC) Number: 871-613-6
• UNII: 4O719B641V
• DSSTox Substance ID: DTXSID40172497
• Nikkaji Number: J47.679J
• Wikidata: Q27260277
• Mol file: 19020-26-9.mol

Synonyms:4-Ethylquinoline;Quinoline, 4-ethyl-;19020-26-9;4O719B641V;CCRIS 7770;UNII-4O719B641V;4-Ethyl-quinoline;SCHEMBL805503;DTXSID40172497;AKOS006370682;SB67997;EN300-1478770;Q27260277

Chemical Property of 4-Ethylquinoline

Chemical Property:

• Vapor Pressure: 0.00973mmHg at 25°C
• Refractive Index: 1.6722 (estimate)
• Boiling Point: 273.2°C at 760 mmHg
• PKA: 5.80±0.13(Predicted)
• Flash Point: 113.1°C
• PSA: 12.89000
• Density: 1.05g/cm³
• LogP: 2.79720
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 157.089149355
• Heavy Atom Count: 12
• Complexity: 144

Purity/Quality:

4-ETHYLQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC1=CC=NC2=CC=CC=C12

Technology Process of 4-Ethylquinoline

There total 40 articles about 4-Ethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C6H4NCH2CHCCH2 (491-35-0) + methyl iodide (74-88-4) → 4-ethylquinoline (19020-26-9)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

DOI:10.1021/jm9806648

Reference yield: 95.0%

2-propionylpyridine (3238-55-9) + 4-chloroquinoline (611-35-8) → 4-ethylquinoline (19020-26-9)

Guidance literature:

With 2.9-dimethyl-1,10-phenanthroline; palladium(II) trifluoroacetate; potassium tert-butylate; In toluene; at 120 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02498

Reference yield: 87.0%

quinoline (91-22-5) + ethyl bromide (74-96-4) → 4-ethylquinoline (19020-26-9)

Guidance literature:

With bis(acetylacetonato)palladium(II); caesium carbonate; trimethylphosphane; In tetrahydrofuran; at 60 ℃; for 5h;

upstream raw materials:

C₆H₄NCH₂CHCCH₂

ethylmagnesium iodide

quinoline-4-carbonitrile

2-chloro-4-ethylquinoline

Downstream raw materials:

4-quinolinic acid

4-[2-(p-methoxyphenoxy)-1-methylethyl]quinoline

4-[1-methyl-2-(p-nitrophenoxy)ethyl]quinoline

4-[2-(tert-butyldiphenylsilyloxy)-1-methylethyl]quinoline