2,5-Diethoxytetrahydrofuran

Base Information

• Chemical Name: 2,5-Diethoxytetrahydrofuran
• CAS No.: 3320-90-9
• Molecular Formula: C8H16 O3
• Molecular Weight: 160.213
• Hs Code.: 2932190090
• European Community (EC) Number: 222-026-3
• NSC Number: 15494
• DSSTox Substance ID: DTXSID10954808
• Nikkaji Number: J113.004H
• Mol file: 3320-90-9.mol

Synonyms:2,5-Diethoxytetrahydrofuran;3320-90-9;2,5-diethoxyoxolane;Furan, 2,5-diethoxytetrahydro-;EINECS 222-026-3;AI3-25060;NSC15494;2,5-DIETHOXY TETRAHYDROFURAN;2,5-Diethoxyoxolanato;Furan,5-diethoxytetrahydro-;SCHEMBL540037;2,5-Diethoxy-tetrahydro-furan;2-5-Diethoxytetrahydrofuran,c&t;DTXSID10954808;MFCD00005361;NSC 15494;NSC-15494;AKOS006228850;FT-0634776;F16813

Chemical Property of 2,5-Diethoxytetrahydrofuran

Chemical Property:

• Vapor Pressure: 1.72mmHg at 25°C
• Refractive Index: 1.4620 (estimate)
• Boiling Point: 173.1°Cat760mmHg
• Flash Point: 56.7°C
• PSA: 27.69000
• Density: 0.98g/cm³
• LogP: 1.52200
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 160.109944368
• Heavy Atom Count: 11
• Complexity: 93.5

Purity/Quality:

99% ^*data from raw suppliers

2,5-Diethoxytetrahydrofuran 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC1CCC(O1)OCC

Technology Process of 2,5-Diethoxytetrahydrofuran

There total 8 articles about 2,5-Diethoxytetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethanol (64-17-5) + (1E,3E)-1,4-Bis-trimethylsilanyloxy-buta-1,3-diene (79668-89-6) → 2,5-diethoxytetrahydrofurane (3320-90-9)

Guidance literature:

With hydrogenchloride; at -70 - -65 ℃;

DOI:10.1016/S0040-4039(00)78703-X

Reference yield:

2-ethoxy-2,5-dimethyl-2,5-dihydrofuran (20295-21-0) → 2,5-diethoxytetrahydrofurane (3320-90-9)

Guidance literature:

With nickel; Hydrogenation;

DOI:10.1021/ja01158a058

Reference yield:

furan (110-00-9) + ethanol (64-17-5) → 2,5-diethoxytetrahydrofurane (3320-90-9)

Guidance literature:

With chlorine; nickel; sodium carbonate; at -15 ℃; Hydrogenation;

upstream raw materials:

furan

ethanol

2-ethoxy-2,5-dimethyl-2,5-dihydrofuran

(1E,3E)-1,4-Bis-trimethylsilanyloxy-buta-1,3-diene

Downstream raw materials:

butanedial

2,2'-butane-1,4-diylidenediamino-bis-benzenethiol

4-(1-pyrrolylmethyl)pyridine

2-N-pyrrolylpyrazine

Refernces

• 1、 Hirai, Kenji,Suzuki, Hiroharu,Moro-oka, Yoshihiko,Ikawa, Tsuneo. "CATALYTIC ISOMERIZATION OF ACETYLENIC SILYL ETHERS TO DIENOL SILYL ETHERS BY RUTHENIUM HYDRIDE COMPLEXES". . p. 3413 - 3416. Retrieved 2007/10/02.