Ethyl 5-amino-4,6-dichloronicotinate

Base Information

• Chemical Name: Ethyl 5-amino-4,6-dichloronicotinate
• CAS No.: 154012-16-5
• Molecular Formula: C8H8Cl2N2O2
• Molecular Weight: 235.06732
• Hs Code.: 2933399090
• Mol file: 154012-16-5.mol

Synonyms:ethylaminodichloronicotinate;ethyl 3-amino-2,4-dichloropyridine-5-carboxylate;ethyl 5-amino-4,6-dichloronicotinate;

Chemical Property of Ethyl 5-amino-4,6-dichloronicotinate

Chemical Property:

• Melting Point: 75-77°
• Boiling Point: 343.9±37.0 °C(Predicted)
• PKA: -0.65±0.10(Predicted)
• PSA: 65.21000
• Density: 1.440±0.06 g/cm3(Predicted)
• LogP: 2.72850
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 5-amino-4,6-dichloronicotinate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 5-amino-4,6-dichloronicotinate

There total 2 articles about Ethyl 5-amino-4,6-dichloronicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl 2,4-dichloro-3-nitropyridine-5-carboxylate (154012-15-4) → ethyl 3-amino-2,4-dichloropyridine-5-carboxylate (154012-16-5)

Guidance literature:

With hydrogen; nickel; In tetrahydrofuran; at 26 - 34 ℃; for 21h; under 1241.2 - 2585.7 Torr;

DOI:10.1002/jhet.5570300402

Reference yield:

ethyl 2,4-dihydroxy-3-nitropyridine-5-carboxylate (6317-97-1) → ethyl 3-amino-2,4-dichloropyridine-5-carboxylate (154012-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / POCl₃ / 48 h / 115 °C

2: 94 percent / H₂ / Raney-nickel / tetrahydrofuran / 21 h / 26 - 34 °C / 1241.2 - 2585.7 Torr

With hydrogen; trichlorophosphate; nickel; In tetrahydrofuran;

DOI:10.1002/jhet.5570300402

Reference yield:

ethyl 3-amino-2,4-dichloropyridine-5-carboxylate (154012-16-5) → ethyl 2,4-dichloro-3-fluoropyridine-5-carboxylate (154012-17-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / hexafluorophosphoric acid, aq. NaNO₂ / 0.08 h

2: 27 percent / 150 °C

With hexafluorophosphoric acid; sodium nitrite;

DOI:10.1002/jhet.5570300402

upstream raw materials:

ethyl 2,4-dichloro-3-nitropyridine-5-carboxylate

ethyl 2,4-dihydroxy-3-nitropyridine-5-carboxylate

Downstream raw materials:

2,4-dichloro-3-fluoropyridine-5-carboxylic acid

ethyl 2,4-dichloro-3-fluoropyridine-5-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 154012-16-5 Ethyl 5-amino-4,6-dichloronicotinate

Send

Send

Metric Ton KG G Pound L ML

Send

Send