4-(1-ADAMANTYL)ANILINE

Base Information

• Chemical Name: 4-(1-ADAMANTYL)ANILINE
• CAS No.: 1459-48-9
• Molecular Formula: C16H21 N
• Molecular Weight: 227.349
• Hs Code.: 2921420090
• Mol file: 1459-48-9.mol

Synonyms:Aniline,p-1-adamantyl- (7CI,8CI); 1-(p-Aminophenyl)adamantane; 4-(1-Adamantyl)aniline;4-(Adamantan-1-yl)phenylamine

Chemical Property of 4-(1-ADAMANTYL)ANILINE

Chemical Property:

• Vapor Pressure: 1.37E-05mmHg at 25°C
• Melting Point: 107-108℃
• Boiling Point: 367.4°C at 760 mmHg
• Flash Point: 154.1°C
• PSA: 26.02000
• Density: 1.132g/cm³
• LogP: 4.31780

Purity/Quality:

98%min ^*data from raw suppliers

4-(1-Adamantyl)aniline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(1-Adamantyl)aniline is used as a reactant in the preparation of pyrroledione derivatives as inhibitors of glycogen synthase kinase-3.

Technology Process of 4-(1-ADAMANTYL)ANILINE

There total 24 articles about 4-(1-ADAMANTYL)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-adamanthanol (768-95-6) → 4-(tricyclo[3.3.1.13,7]dec-1-yl)aniline (1459-48-9)

Guidance literature:

With hydrogenchloride; sodium hydroxide; aniline; Zinc chloride; In nitrogen; water;

Reference yield: 77.0%

1-(4-nitrophenyl)adamantane (1459-49-0) → 4-(tricyclo[3.3.1.13,7]dec-1-yl)aniline (1459-48-9)

Guidance literature:

With hydrogenchloride; iron; In methanol; Reflux;

DOI:10.1021/acs.joc.0c02917

Reference yield: 73.0%

1-adamanthanol (768-95-6) + aniline (62-53-3) → 4-(tricyclo[3.3.1.13,7]dec-1-yl)aniline (1459-48-9) + (3s,5s,7s)-N-phenyladamantan-1-amine (33187-62-1) + 1-(3-aminophenyl)adamantane (60029-40-5) + 2-(1-adamantyl)aniline (143571-14-6)

Guidance literature:

With aniline; aluminium anilide; In various solvent(s); at 175 ℃; for 9h; Further byproducts given;

upstream raw materials:

1-(4-nitrophenyl)adamantane

N-(4-((3r,5r,7r)-adamantan-1-yl)phenyl)acetamide

1-Adamantyl bromide

aniline

Downstream raw materials:

4-(adamantan-1-yl)benzonitrile

1-(4-chlorophenyl)adamantane

ethyl {[4-(adamantan-1-yl)phenyl]amino}oxoacetate

Refernces

• 1、 -. "Nitrogen-containing compound, electronic element, and electronic device". Paragraph 0187; 0202-0204. . Retrieved 2021/03/24.
• 2、 -. "NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS". Page/Page column 108. . Retrieved 2020/10/09.