1,2,3,4-Tetrahydro-1-(3-pyridylcarbonyl)quinolin-8-ol

Base Information

Chemical Name:1,2,3,4-Tetrahydro-1-(3-pyridylcarbonyl)quinolin-8-ol
CAS No.:77771-22-3
Molecular Formula:C₁₅H₁₄N₂O₂
Molecular Weight:254.288
Hs Code.:
European Community (EC) Number:278-765-7
DSSTox Substance ID:DTXSID90998962
Nikkaji Number:J319.688G
Wikidata:Q82991786
Mol file:77771-22-3.mol

Synonyms:77771-22-3;1,2,3,4-Tetrahydro-1-(3-pyridylcarbonyl)quinolin-8-ol;EINECS 278-765-7;(8-Hydroxy-3,4-dihydroquinolin-1(2H)-yl)(pyridin-3-yl)methanone;SCHEMBL10568480;DTXSID90998962;GUQABSUKMJPZHH-UHFFFAOYSA-N;AKOS006174976;1-nicotinoyl-8-hydroxy-1,2,3,4-tetrahydroquinoline;8-hydroxy-1-nicotinoyl-1,2,3,4-tetrahydroquinoline;1,2,3,4-Tetrahydro-1-(3-pyridinylcarbonyl)-8-quinolinol

Suppliers and Price of 1,2,3,4-Tetrahydro-1-(3-pyridylcarbonyl)quinolin-8-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 1,2,3,4-Tetrahydro-1-(3-pyridylcarbonyl)quinolin-8-ol

Chemical Property:

Vapor Pressure:3.51E-09mmHg at 25°C
Boiling Point:462.7°C at 760 mmHg
Flash Point:233.6°C
PSA：53.43000
Density:1.297g/cm³
LogP:2.44520
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:254.105527694
Heavy Atom Count:19
Complexity:334

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2=C(C(=CC=C2)O)N(C1)C(=O)C3=CN=CC=C3

Technology Process of 1,2,3,4-Tetrahydro-1-(3-pyridylcarbonyl)quinolin-8-ol

There total 2 articles about 1,2,3,4-Tetrahydro-1-(3-pyridylcarbonyl)quinolin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 10400-19-8
3-pyridinecarbonyl chloride

: 6640-50-2
1,2,3,4-tetrahydroquinolin-8-ol

: 77771-22-3
1-nicotinoyl-8-hydroxy-1,2,3,4-tetrahydroquinoline

Guidance literature:: With triethylamine; In toluene; at 20 ℃; Schlenk technique; Inert atmosphere;
DOI:10.1039/c9ob02673h

Reference yield:

: 148-24-3,24804-14-6
8-quinolinol

: 77771-22-3
1-nicotinoyl-8-hydroxy-1,2,3,4-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; boric acid / 1,2-dichloro-ethane / 7 h / 60 °C

2: triethylamine / toluene / 20 °C / Schlenk technique; Inert atmosphere

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; boric acid; triethylamine; In 1,2-dichloro-ethane; toluene;
DOI:10.1039/c9ob02673h