Bupranolol

Base Information

Chemical Name:Bupranolol
CAS No.:14556-46-8
Deprecated CAS:70578-42-6
Molecular Formula:C14H22 Cl N O2
Molecular Weight:271.787
Hs Code.:2922509090
UNII:858YGI5PIT
DSSTox Substance ID:DTXSID7022704
Nikkaji Number:J8.508A
Wikipedia:Bupranolol
Wikidata:Q425838
NCI Thesaurus Code:C72615
Pharos Ligand ID:PYNR6FZ8R15Y
Metabolomics Workbench ID:43724
ChEMBL ID:CHEMBL305380
Mol file:14556-46-8.mol

Synonyms:Betadrenol;Bupranolol;KL 255;KL-255;KL255

Suppliers and Price of Bupranolol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Bupranolol
500mg
$ 215.00

Medical Isotopes, Inc.
Bupranolol
5 g
$ 2400.00

American Custom Chemicals Corporation
BUPRANOLOL 95.00%
5MG
$ 496.82

Total 8 raw suppliers

Chemical Property of Bupranolol

Chemical Property:

Vapor Pressure:5.44E-07mmHg at 25°C
Boiling Point:396.3°Cat760mmHg
Flash Point:193.5°C
PSA：41.49000
Density:1.098g/cm³
LogP:3.16710
Storage Temp.:Hygroscopic, Refrigerator, Under Inert Atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:271.1339066
Heavy Atom Count:18
Complexity:242

Purity/Quality:

97% ^*data from raw suppliers

Bupranolol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C=C1)Cl)OCC(CNC(C)(C)C)O
Uses Bupranolol is an antagonist at the cardiostimulatory low-affinity state of b(1)-adrenoceptors and is known to treat hypertension and tachycardia.
Therapeutic Function Antiarrhythmic

Technology Process of Bupranolol

There total 4 articles about Bupranolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 615-74-7
2-chloro-5-methylphenol

: 75-64-9
tert-butylamine

: 106-89-8,24969-06-0,13403-37-7
epichlorohydrin

: 14556-46-8,61877-83-6,38104-34-6
bupranolol

Guidance literature:: With sodium hydroxide; In water; at 50 ℃; for 5h;
DOI:10.1016/j.molstruc.2018.06.079

Reference yield:

: 53732-26-6
1,2-epoxy-3-[2-chloro-5-methylphenoxy]propane

: 75-64-9
tert-butylamine

: 14556-46-8,61877-83-6,38104-34-6
bupranolol

Guidance literature:: In ethanol; toluene; at 120 ℃; for 0.333333h; under 3900.39 Torr; Flow reactor;
DOI:10.1039/c5cc06093a

Reference yield:

: 615-74-7
2-chloro-5-methylphenol

: 14556-46-8,61877-83-6,38104-34-6
bupranolol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; tetrabutyl-ammonium chloride / water / 1 h / 45 °C / Flow reactor

2: ethanol; toluene / 0.33 h / 120 °C / 3900.39 Torr / Flow reactor

With tetrabutyl-ammonium chloride; sodium hydroxide; In ethanol; water; toluene;
DOI:10.1039/c5cc06093a