(6Z)-6-[(hydroxyamino)methylidene]-4-methylcyclohexa-2,4-dien-1-one

Base Information

• Chemical Name: (6Z)-6-[(hydroxyamino)methylidene]-4-methylcyclohexa-2,4-dien-1-one
• CAS No.: 1726-86-9
• Molecular Formula: C8H9 N O2
• Molecular Weight: 151.165
• Mol file: 1726-86-9.mol

Synonyms:2,5-Cresotaldehyde,oxime (7CI); 2-Hydroxy-5-methylbenzaldehyde oxime;5-Methyl-2-hydroxybenzaldehyde oxime; 5-Methylsalicylaldehyde oxime

Chemical Property of (6Z)-6-[(hydroxyamino)methylidene]-4-methylcyclohexa-2,4-dien-1-one

Chemical Property:

• Vapor Pressure: 0.000148mmHg at 25°C
• Boiling Point: 296.4°C at 760 mmHg
• Flash Point: 133.1°C
• Density: 1.319g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6Z)-6-[(hydroxyamino)methylidene]-4-methylcyclohexa-2,4-dien-1-one

There total 4 articles about (6Z)-6-[(hydroxyamino)methylidene]-4-methylcyclohexa-2,4-dien-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-hydroxy-5-methylbenzaldehyde (613-84-3) → 2-hydroxy-5-methylbenzaldehyde oxime (1726-86-9)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; at 20 ℃; for 0.5h;

DOI:10.17344/acsi.2018.4749

Reference yield: 73.8%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + p-cresol (106-44-5) → 2,2'-methylenebis(4-methylphenol) (3236-63-3) + 2-hydroxy-5-methylbenzaldehyde (613-84-3) + 2-hydroxy-5-methylbenzaldehyde oxime (1726-86-9)

Guidance literature:

With hydroxylamine sulfate; magnesium methanolate; Product distribution; multistep reaction: 1.) MeOH, toluene, reflux, 1 h, 2.) 95 deg C, 1.25 h, 3.) H₂O, 55 deg C, 1 h; magnesium-mediated ortho-specific formylation and formaldoximation of substituted phenols, effect of the substituent;

Reference yield:

→ 2-hydroxy-5-methylbenzaldehyde oxime (1726-86-9)

Guidance literature:

With ethanol; hydroxylamine hydrochloride; sodium carbonate;

upstream raw materials:

2-hydroxy-5-methylbenzaldehyde

formaldehyd

p-cresol

Downstream raw materials:

2-hydroxy-5-methylbenzylamine

5-methylbenzo[d]isoxazole

4,4'-dimethyl-2,2'-(2-aza-propanediyl)-di-phenol