NAT 02-677

Base Information

• Chemical Name: NAT 02-677
• CAS No.: 54996-53-1
• Molecular Formula: C8H7 N O Se
• Molecular Weight: 212.10728
• Hs Code.: 2927000090
• Mol file: 54996-53-1.mol

Synonyms:2-Methyl-1,2-benzisoselenazol-3(2H)-one;2-Methyl-2H-1,2-benzisoselenazol-3-one; NAT 02-677

Chemical Property of NAT 02-677

Chemical Property:

• Vapor Pressure: 0.000588mmHg at 25°C
• Boiling Point: 310.8°C at 760 mmHg
• Flash Point: 141.7°C
• PSA: 22.00000
• LogP: 0.59550

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of NAT 02-677

There total 12 articles about NAT 02-677 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-iodo-N-methyl-benzamide (58084-22-3) → 2-methylbenzo[d][1,2]selenazol-3(2H)-one (54996-53-1)

Guidance literature:

With selenium; copper(l) iodide; 1,10-Phenanthroline; potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol102027j

Reference yield: 84.0%

2-(chloroseleno)benzoyl chloride (1441-85-6) + methylamine (74-89-5) → 2-methylbenzo[d][1,2]selenazol-3(2H)-one (54996-53-1)

Guidance literature:

In water; for 2h; Ambient temperature;

Reference yield: 77.0%

N-methylbenzamide (88070-48-8) → 2-methylbenzo[d][1,2]selenazol-3(2H)-one (54996-53-1)

Guidance literature:

With selenium; tris(acetonitrile)(η5-pentamethylcyclopentadienyl)rhodium(III) hexafluoroantimonate; silver(I) acetate; acetic acid; at 80 ℃; for 24h; Reagent/catalyst; Temperature; Inert atmosphere; Schlenk technique; Darkness;

DOI:10.1002/chem.202103485

upstream raw materials:

2-(chloroseleno)benzoyl chloride

methylamine

2-methyl-benzo[d]isoselenazole-3-thione

3-chloro-2-methyl-benzo[d]isoselenazolium; chloride

Downstream raw materials:

3-chloro-2-methyl-benzo[d]isoselenazolium; chloride

bis<2-(N-methylcarboxamido)phenyl> diselenide

C₁₄H₁₃NOSSe