DIETHYL (3-CHLOROPROPYL)MALONATE

Base Information

• Chemical Name: DIETHYL (3-CHLOROPROPYL)MALONATE
• CAS No.: 18719-43-2
• Molecular Formula: C10H17ClO4
• Molecular Weight: 236.696
• Hs Code.: 2922.49 DERIVATION
• Mol file: 18719-43-2.mol

Synonyms:Malonicacid, (3-chloropropyl)-, diethyl ester (6CI,8CI);Propanedioic acid,(3-chloropropyl)-, diethyl ester (9CI);Chloropropylmalonic acid diethyl ester;Diethyl (3-chloropropyl)malonate;Diethyl (g-chloropropyl)malonate;

Chemical Property of DIETHYL (3-CHLOROPROPYL)MALONATE

Chemical Property:

• Appearance/Colour: clear to pale yellow liquid
• Vapor Pressure: 0.0021mmHg at 25°C
• Refractive Index: n20/D 1.443(lit.)
• Boiling Point: 290.2 °C at 760 mmHg
• PKA: 12.66±0.59(Predicted)
• Flash Point: 111.9 °C
• PSA: 52.60000
• Density: 1.114 g/cm³
• LogP: 1.74780

Purity/Quality:

97% ^*data from raw suppliers

Diethyl (3-chloropropyl)malonate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of DIETHYL (3-CHLOROPROPYL)MALONATE

There total 5 articles about DIETHYL (3-CHLOROPROPYL)MALONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1.3-chlorobromopropane (109-70-6) + diethyl malonate (105-53-3) → diethyl (3-chloropropyl)malonate (18719-43-2)

Guidance literature:

diethyl malonate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.25h; Inert atmosphere;

1.3-chlorobromopropane; In N,N-dimethyl-formamide; mineral oil; at 0 - 25 ℃; for 2h; Inert atmosphere;

DOI:10.3762/bjoc.17.135

Reference yield:

1,3-Dichloropropane (142-28-9) + diethyl malonate (105-53-3) → diethyl (3-chloropropyl)malonate (18719-43-2) + diethyl cyclobutane-1,1-dicarboxylate (3779-29-1)

Guidance literature:

With tetrabutylammomium bromide; cyclohexene; In acetonitrile; at 20 ℃; Pt cathode, I = 80 mA, electrolysis;

DOI:10.1007/BF00961301

Reference yield:

1-iodo-3-chloro-propane (6940-76-7) + diethyl malonate (105-53-3) → diethyl (3-chloropropyl)malonate (18719-43-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Inert atmosphere;

DOI:10.1021/ja301415k

upstream raw materials:

1.3-chlorobromopropane

diethyl malonate

1,3-Dichloropropane

1-iodo-3-chloro-propane

Downstream raw materials:

5-chloro-valeric acid

diethyl cyclobutane-1,1-dicarboxylate

4-(3-chloro-propyl)-2-phenyl-isoxazolidine-3,5-dione

diethyl ethyl(3-chloropropyl)malonate