METHYLGLYCERIN

Base Information

• Chemical Name: METHYLGLYCERIN
• CAS No.: 25245-58-3
• Molecular Formula: C4H10O3
• Molecular Weight: 106.122
• Hs Code.: 2905499000
• Mol file: 25245-58-3.mol

Synonyms:2-Hydroxy-2-methyl-1,3-propanediol;2-Methyl-1,2,3-propanetriol;2-Methylglycerin;2-Methylglycerol;NSC 403834;

Chemical Property of METHYLGLYCERIN

Chemical Property:

• Vapor Pressure: 0.000412mmHg at 25°C
• Refractive Index: 1.489
• Boiling Point: 281.8 °C at 760 mmHg
• PKA: 13.75±0.29(Predicted)
• Flash Point: 145.8 °C
• PSA: 60.69000
• Density: 1.217 g/cm³
• LogP: -1.27800

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-1,2,3-propanetriol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYLGLYCERIN

There total 13 articles about METHYLGLYCERIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-hydroxy-2-methyl-1-propene (513-42-8) → 2-methylpropane-1,2,3-triol (25245-58-3)

Guidance literature:

3-hydroxy-2-methyl-1-propene; With dihydrogen peroxide; bis(2,4-pentanedionato)dioxomolybdenum(VI); In acetonitrile; at 30 ℃;

With diphenyl sulfide; regioselective reaction;

DOI:10.1021/acscatal.8b01449

Reference yield: 88.0%

(3S)-3,4-dihydroxybutan-2-one → 2-methylpropane-1,2,3-triol (25245-58-3)

Guidance literature:

With β-nicotinamide adenine dinucleotide 2'-phosphate reduced tetra(cyclohexylammonium) salt; M_. tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase; magnesium chloride; In aq. phosphate buffer; at 25 ℃; for 144h; pH=7.5; Kinetics; Enzymatic reaction;

DOI:10.1021/bi400092n

Reference yield: 80.0%

2-methylglycidol (872-30-0) → 2-methylpropane-1,2,3-triol (25245-58-3)

Guidance literature:

With Amberlyst A 26 (CO₃^2- form); In benzene; for 6h; Heating;

DOI:10.1021/jo00145a004

upstream raw materials:

1,3-dichloro-2-methyl-propan-2-ol

3-chloro-2-methyl-propane-1,2-diol

3-hydroxy-2-methyl-1-propene

2-Methyl-2-nitro-1,3-propanediol

Downstream raw materials:

2-methylpropenal

4-methyl-2,6,7-trioxa-1-phosphabicyclo[2,2,1]heptane

2-methyl-1,3-di-O-trityl-1,2,3-propanetriol

(4RS)-4-hydroxymethyl-2,2,4-trimethyl-1,3-dioxolane

Refernces

• 1、 Vande Griend,L.J. et al.. "-". . p. 2459 - 2463. Retrieved 1977.
• 2、 Fan, Pei,Su, Shixia,Wang, Chuan. "Molybdenum-Catalyzed Hydroxyl-Directed Anti-Dihydroxylation of Allylic and Homoallylic Alcohols". . p. 6820 - 6826. Retrieved 2018/06/22.
• 3、 Bolduc, Melanie,Bergeron, Jerome,Michaud, Annie,Pelchat, Nicholas,Morin, Pierre,Dasser, Mohammed,Chenevert, Robert. "Chemoenzymatic enantioselective synthesis of 2-substituted glycerol derivatives". experimental part. p. 428 - 433. Retrieved 2012/07/28.