biphenyl-4-yl(phenyl)acetic acid

Base Information

• Chemical Name: biphenyl-4-yl(phenyl)acetic acid
• CAS No.: 5449-50-3
• Molecular Formula: C20H16O2
• Molecular Weight: 288.346
• Mol file: 5449-50-3.mol

Synonyms:

Chemical Property of biphenyl-4-yl(phenyl)acetic acid

Chemical Property:

• Vapor Pressure: 1.86E-07mmHg at 25°C
• Boiling Point: 410°C at 760 mmHg
• Flash Point: 215.9°C
• Density: 1.172g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of biphenyl-4-yl(phenyl)acetic acid

There total 9 articles about biphenyl-4-yl(phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

carbon dioxide (124-38-9,18923-20-1) + 1-([1,1'-biphenyl]-4-yl)-N,N,N-trimethyl-1-phenylmethanaminium trifluoromethanesulfonate → biphenyl-4-yl-phenyl-acetic acid (5449-50-3)

Guidance literature:

With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; sodium carbonate; caesium carbonate; In N,N-dimethyl-formamide; at 25 - 30 ℃; for 36h; Schlenk technique; Glovebox; Sealed tube; Irradiation;

DOI:10.1021/jacs.8b08792

Reference yield: 78.0%

carbon dioxide (124-38-9,18923-20-1) + C19H16N2 → biphenyl-4-yl-phenyl-acetic acid (5449-50-3)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; caesium carbonate; cesium fluoride; In N,N-dimethyl-formamide; at 80 ℃; for 24h; under 760.051 Torr; chemoselective reaction;

DOI:10.1039/c8sc01299g

Reference yield: 28.0%

carbon dioxide (124-38-9,18923-20-1) + 4-benzylbiphenyl (613-42-3) → biphenyl-4-yl-phenyl-acetic acid (5449-50-3)

Guidance literature:

4-benzylbiphenyl; With n-butyllithium; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 1h;

carbon dioxide; In tetrahydrofuran; hexane; at 20 ℃; for 0.5h;

With hydrogenchloride; In tetrahydrofuran; hexane; water; pH=6;

upstream raw materials:

2-([1,1'-biphenyl]-4-yl)-2-hydroxy-2-phenylacetic acid

biphenyl

ethyl (4-phenylphenyl)glyoxylate

carbon dioxide

Downstream raw materials:

2-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-phenylacetamide

(E)-4-phenylstilbene