6-(p-Chloro-N-propylbenzylamino)-2,4-diaminopyrido(3,2-d)pyrimidine

Base Information

Chemical Name:6-(p-Chloro-N-propylbenzylamino)-2,4-diaminopyrido(3,2-d)pyrimidine
CAS No.:93683-96-6
Molecular Formula:C₁₇H₁₉ClN₆
Molecular Weight:342.831
Hs Code.:
ChEMBL ID:CHEMBL84323
DSSTox Substance ID:DTXSID60918213
Wikidata:Q82890184

Synonyms:BRN 6435578;6-(p-Chloro-N-propylbenzylamino)-2,4-diaminopyrido(3,2-d)pyrimidine;93683-96-6;Pyrido(3,2-d)pyrimidine, 6-(p-chloro-N-propylbenzylamino)-2,4-diamino-;CHEMBL84323;DTXSID60918213;N-[(4-Chlorophenyl)methyl]-2,4-diimino-N-propyl-1,2,3,4-tetrahydropyrido[3,2-d]pyrimidin-6-amine

Suppliers and Price of 6-(p-Chloro-N-propylbenzylamino)-2,4-diaminopyrido(3,2-d)pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 6-(p-Chloro-N-propylbenzylamino)-2,4-diaminopyrido(3,2-d)pyrimidine

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:342.1359723
Heavy Atom Count:24
Complexity:389

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCN(CC1=CC=C(C=C1)Cl)C2=NC3=C(C=C2)N=C(N=C3N)N

Technology Process of 6-(p-Chloro-N-propylbenzylamino)-2,4-diaminopyrido(3,2-d)pyrimidine

There total 4 articles about 6-(p-Chloro-N-propylbenzylamino)-2,4-diaminopyrido(3,2-d)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 29671-92-9
chloroformamidine hydrochloride

: 93683-84-2
3-Amino-6-[(4-chloro-benzyl)-propyl-amino]-pyridine-2-carbonitrile

: 93683-96-6
2,4-diamino-6-<(p-chlorobenzyl)propylamino>pyrido<3,2-d>pyrimidine

Guidance literature:: In dimethyl sulfoxide; at 130 ℃; for 1h;
DOI:10.1021/jm00380a018

Reference yield:

: 55245-43-7
N-(4-chlorobenzyl)propan-1-amine

: 93683-96-6
2,4-diamino-6-<(p-chlorobenzyl)propylamino>pyrido<3,2-d>pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / Et₃N / 2-ethoxy-ethanol / 1 h / Heating

2: 63 percent / Fe, conc. aq. HCl / 1 h / Heating

3: 53 percent / dimethylsulfoxide / 1 h / 130 °C

With hydrogenchloride; iron; triethylamine; In 2-ethoxy-ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00380a018

Reference yield:

: 93683-65-9
6-chloro-3-nitropicolinonitrile

: 93683-96-6
2,4-diamino-6-<(p-chlorobenzyl)propylamino>pyrido<3,2-d>pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / Et₃N / 2-ethoxy-ethanol / 1 h / Heating

2: 63 percent / Fe, conc. aq. HCl / 1 h / Heating

3: 53 percent / dimethylsulfoxide / 1 h / 130 °C

With hydrogenchloride; iron; triethylamine; In 2-ethoxy-ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00380a018