2,3-dihydroxybenzoyl-N-glycine

Base Information

• Chemical Name: 2,3-dihydroxybenzoyl-N-glycine
• CAS No.: 16414-49-6
• Molecular Formula: C9H9 N O5
• Molecular Weight: 211.17
• Mol file: 16414-49-6.mol

Synonyms:Glycine,N-o-pyrocatechuoyl- (6CI); Hippuric acid, 2,3-dihydroxy- (8CI);2,3-Dihydroxybenzoylglycine; Itoic acid; N-(2,3-Dihydroxybenzoyl)glycine

Chemical Property of 2,3-dihydroxybenzoyl-N-glycine

Chemical Property:

• Vapor Pressure: 1.77E-10mmHg at 25°C
• Boiling Point: 491.6°Cat760mmHg
• Flash Point: 251.1°C
• PSA: 106.86000
• Density: 1.532g/cm³
• LogP: 0.30310

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-dihydroxybenzoyl-N-glycine

There total 3 articles about 2,3-dihydroxybenzoyl-N-glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

ethyl 2-[(2,3-dihydroxybenzoyl)amino]acetate → 2-[(2,3-dihydroxybenzoyl)amino]acetic acid (16414-49-6)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 4h;

DOI:10.1248/cpb.50.578

Reference yield:

2,3-Dihydroxybenzoic acid (303-38-8) + GlyOEt*HCl (459-73-4) → 2-[(2,3-dihydroxybenzoyl)amino]acetic acid (16414-49-6)

Guidance literature:

With dicyclohexyl-carbodiimide;

DOI:10.1021/ja01550a058

Reference yield:

2,3-Dihydroxybenzoic acid (303-38-8) → 2-[(2,3-dihydroxybenzoyl)amino]acetic acid (16414-49-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / 1,3-dicyclohexylcarbodiimide; triethylamine / tetrahydrofuran / 16 h / 20 °C

2: 84 percent / aq. NaOH / 4 h / 20 °C

With sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran;

DOI:10.1248/cpb.50.578

upstream raw materials:

2,3-Dihydroxybenzoic acid

GlyOEt*HCl

Refernces

• 1、 Lienard, Benoit M.,Conejo-Garcia, Ana,Stolze, Ineke,Loenarz, Christoph,Oldham, Neil J.,Ratcliffe, Peter J.,Schofield, Christopher J.. "Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases". supporting information; experimental part. p. 6393 - 6395. Retrieved 2009/04/13.