5-(4-Methoxyphenyl)-5-methylimidazolidine-2,4-dione

Base Information

• Chemical Name: 5-(4-Methoxyphenyl)-5-methylimidazolidine-2,4-dione
• CAS No.: 22927-78-2
• Molecular Formula: C11H12 N2 O3
• Molecular Weight: 220.228
• Hs Code.: 2933990090
• European Community (EC) Number: 831-988-9
• DSSTox Substance ID: DTXSID00945609
• Nikkaji Number: J77.748J
• Mol file: 22927-78-2.mol

Synonyms:22927-78-2;5-(4-methoxyphenyl)-5-methylimidazolidine-2,4-dione;5-p-Methoxyphenyl-5-methylhydantoin;5-(p-methoxyphenyl)-5-methyl-hydantoi;Hydantoin, 5-(p-methoxyphenyl)-5-methyl-;2,4-Imidazolidinedione, 5-(4-methoxyphenyl)-5-methyl-;5-(4-Methoxy-phenyl)-5-methyl-imidazolidine-2,4-dione;Oprea1_666554;Oprea1_706463;SCHEMBL539101;DTXSID00945609;C11H13N2O3;AKOS000263808;AKOS017268948;C11-H13-N2-O3;5-(p-Methoxyphenyl)-5-methylhydantoin;5-methyl-5-(4-methoxyphenyl)hydantoin;SDCCGMLS-0064756.P001;rac-5-methyl-p-methoxy-5phenylhydantoin;LS-76234;CS-0219577;EN300-04374;BIPHENYL-2,2-DICARBOXYLICACIDDIMETHYLESTER;4-(4-Methoxyphenyl)-4-methyl-4H-imidazole-2,5-diol;Z56862738

Chemical Property of 5-(4-Methoxyphenyl)-5-methylimidazolidine-2,4-dione

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 74.41000
• Density: 1.22g/cm³
• LogP: 0.66570
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 220.08479225
• Heavy Atom Count: 16
• Complexity: 310

Purity/Quality:

99% ^*data from raw suppliers

5-(4-methoxyphenyl)-5-methylimidazolidine-2,4-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(C(=O)NC(=O)N1)C2=CC=C(C=C2)OC

Technology Process of 5-(4-Methoxyphenyl)-5-methylimidazolidine-2,4-dione

There total 8 articles about 5-(4-Methoxyphenyl)-5-methylimidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

sodium cyanide (143-33-9,25596-52-5) + ammonium carbonate (506-87-6,6721-33-1,10361-29-2) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 5-(4-methoxyphenyl)-5-methyl-2,4-imidazolidinedione (22927-78-2)

Guidance literature:

In ethanol; water; at 45 ℃; for 5h; Product distribution; ultrasonication: other temperature, reaction time, absence of ultrasonication);

Reference yield: 47.0%

sodium cyanide (773837-37-9) + ammonium carbonate (506-87-6,6721-33-1,10361-29-2) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 5-(4-methoxyphenyl)-5-methyl-2,4-imidazolidinedione (22927-78-2)

Guidance literature:

In ethanol; water; at 20 - 100 ℃; for 1h;

DOI:10.1016/j.bmcl.2015.01.047

Reference yield:

potassium cyanide + ammonium carbonate (506-87-6,6721-33-1,10361-29-2) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 5-(4-methoxyphenyl)-5-methyl-2,4-imidazolidinedione (22927-78-2)

Guidance literature:

In ethanol; at 60 ℃; for 15h;

DOI:10.2298/JSC120719118H

upstream raw materials:

sodium cyanide

ammonium carbonate

1-(4-methoxyphenyl)ethanone

water

Downstream raw materials:

2-(4-methoxyphenyl)-2-methylglycine

5-(4-methoxyphenyl)-5-methyl-3-(4-(2-oxo-8-n-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)butyl)imidazolidine-2,4-dione

5-(4-methoxyphenyl)-5-methyl-3-(4-(2-oxo-6,8-di-n-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)butyl)imidazolidine-2,4-dione

3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-(4-methoxyphenyl)-5-methylimidazolidine-2,4-dione