(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile

Base Information

Chemical Name:(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile
CAS No.:959691-76-0
Molecular Formula:C₁₉H₁₇N₃O₄
Molecular Weight:351.362
Hs Code.:

Synonyms:(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile

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Chemical Property of (R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile

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Technology Process of (R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile

There total 9 articles about (R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 959691-71-5
(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile

: 959691-76-0
(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile

Guidance literature:: (R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile; With boron dimethyl-trifluoro sulphide; In dichloromethane; at 20 ℃; for 12h;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 84954-08-5
4-cyano-3-methoxyphenyl isocyanate

: 959691-76-0
(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

2.1: sodium hydride / N,N-dimethyl acetamide; mineral oil / 0 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: boron dimethyl-trifluoro sulphide / dichloromethane / 12 h / 20 °C / Inert atmosphere

With boron dimethyl-trifluoro sulphide; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; mineral oil;
DOI:10.1021/jm300249m

Reference yield:

: 197643-97-3
C₁₂H₁₅NO₄

: 959691-76-0
(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-2-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: (R)-1-phenyl-ethyl-amine / ethanol / 20 - 40 °C / Inert atmosphere

1.2: 0.75 h / 20 °C / pH 1 / Inert atmosphere

2.1: hydrogenchloride / 3 h / Inert atmosphere; Reflux

3.1: hydrogenchloride / 0 °C / Inert atmosphere; Reflux

3.2: Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

5.1: sodium hydride / N,N-dimethyl acetamide; mineral oil / 0 °C / Inert atmosphere

5.2: 2 h / 20 °C / Inert atmosphere

6.1: boron dimethyl-trifluoro sulphide / dichloromethane / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; boron dimethyl-trifluoro sulphide; (R)-1-phenyl-ethyl-amine; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; mineral oil;
DOI:10.1021/jm300249m