2-IMIDAZOL-1-YL-PHENYLAMINE

Base Information

• Chemical Name: 2-IMIDAZOL-1-YL-PHENYLAMINE
• CAS No.: 26286-54-4
• Molecular Formula: C9H9N3
• Molecular Weight: 159.191
• Hs Code.: 2933290090
• Mol file: 26286-54-4.mol

Synonyms:Imidazole,1-(o-aminophenyl)- (8CI);1-(2-Aminophenyl)imidazole;2-(Imidazol-1-yl)phenylamine;N-(o-Aminophenyl)imidazole;NSC 266463;

Chemical Property of 2-IMIDAZOL-1-YL-PHENYLAMINE

Chemical Property:

• Vapor Pressure: 5E-05mmHg at 25°C
• Melting Point: 106 °C
• Refractive Index: 1.641
• Boiling Point: 348.5 °C at 760 mmHg
• Flash Point: 164.6 °C
• PSA: 43.84000
• Density: 1.2 g/cm³
• LogP: 2.03570
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

2-(1H-Imidazol-1-yl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(1H-Imidazol-1-yl)aniline is a drug candidate that inhibit the D-loop activity of RAD51.

Technology Process of 2-IMIDAZOL-1-YL-PHENYLAMINE

There total 9 articles about 2-IMIDAZOL-1-YL-PHENYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(2-nitrophenyl)-1H-imidazole (23309-16-2) → 1-(2-aminophenyl)imidazole (26286-54-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 4h; under 2280 Torr; Ambient temperature;

DOI:10.1039/a700457e

Reference yield: 86.0%

1H-imidazole (288-32-4) + 2-bromoaniline (615-36-1) → 1-(2-aminophenyl)imidazole (26286-54-4)

Guidance literature:

With copper(I) oxide; 8-quinolinol; caesium carbonate; In acetonitrile; at 100 ℃; for 72h; Sealed tube; Under air;

DOI:10.1039/c1dt10753d

Reference yield: 75.0%

1H-imidazole (288-32-4) + 2-iodophenylamine (615-43-0) → 1-(2-aminophenyl)imidazole (26286-54-4)

Guidance literature:

With copper(l) iodide; 1H-tetrazol-1-ylacetic acid; sodium hydroxide; In dimethyl sulfoxide; at 110 ℃; for 12h; chemoselective reaction; Sealed tube;

DOI:10.1016/j.cclet.2013.05.037

upstream raw materials:

1-(2-nitrophenyl)-1H-imidazole

ortho-nitrofluorobenzene

1H-imidazole

2-iodophenylamine

Downstream raw materials:

4-chloro-N-<2-(imidazol-1-yl)phenyl>benzamide

9-Imidazo<1,2-a>benzimidazole

2-(3-isopropyl-1H-imidazolium)phenylamine iodide