Succinyldisalicylic acid

Base Information

• Chemical Name: Succinyldisalicylic acid
• CAS No.: 578-19-8
• Molecular Formula: C18H14 O8
• Molecular Weight: 358.304
• European Community (EC) Number: 209-420-0
• NSC Number: 518104
• DSSTox Substance ID: DTXSID40206488
• Nikkaji Number: J278.892F
• Wikidata: Q83080309
• ChEMBL ID: CHEMBL1161014
• Mol file: 578-19-8.mol

Synonyms:bis(o-carboxyphenyl)succinate;diaspirin;succinyldisalicylic acid

Chemical Property of Succinyldisalicylic acid

Chemical Property:

• Vapor Pressure: 9.8E-16mmHg at 25°C
• Melting Point: 160-165 °C(lit.)
• Boiling Point: 610°Cat760mmHg
• PKA: 2.68±0.36(Predicted)
• Flash Point: 223.2°C
• PSA: 127.20000
• Density: 1.429g/cm³
• LogP: 2.37420
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 9
• Exact Mass: 358.06886740
• Heavy Atom Count: 26
• Complexity: 495

Purity/Quality:

99%, ^*data from raw suppliers

2,2'-(Succinylbis(oxy))dibenzoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)O)OC(=O)CCC(=O)OC2=CC=CC=C2C(=O)O

Technology Process of Succinyldisalicylic acid

There total 1 articles about Succinyldisalicylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

succinoyl dichloride (543-20-4) + salicylic acid (69-72-7,25496-36-0,8052-31-1) → bis(o-carboxyphenyl)succinate (578-19-8)

Guidance literature:

With 2,3-Dimethylaniline; benzene;

Reference yield:

bis(o-carboxyphenyl)succinate (578-19-8) → succinic acid (110-15-6) + salicylic acid (69-72-7,25496-36-0,8052-31-1)

Guidance literature:

Reference yield:

holmium(III) nitrate pentahydrate + bis(o-carboxyphenyl)succinate (578-19-8) → 2Ho(3+)*3O2CC2H4CO2(2-)*2H2O*0.33HOC6H4COOH=Ho2(O2CC2H4CO2)3(H2O)2*0.33HOC6H4COOH

Guidance literature:

With triethylamine; In water; High Pressure; the mixt. of Ho-salt, succinylsalicylic acid in water, pH 5.5 (triethylamine), heated for 65 h at 160°C (or 1 h at 105°C) in a Teflon-lined digestion bomb, cooled to room temp.; crystals were filtered, washed with distilled water and acetone, dried at ambient temp.;

DOI:10.1021/ic102472u

upstream raw materials:

succinoyl dichloride

salicylic acid

Downstream raw materials:

succinic acid

salicylic acid

Refernces

• 1、 -. "Anticalculus oral composition". . . Retrieved 2008/06/13.