8-((Diethylamino)methyl)-4'-fluoro-7-methoxy-3-methylflavone

Base Information

Chemical Name:8-((Diethylamino)methyl)-4'-fluoro-7-methoxy-3-methylflavone
CAS No.:86073-56-5
Molecular Formula:C₂₂H₂₄FNO₃
Molecular Weight:369.436
Hs Code.:
DSSTox Substance ID:DTXSID10235381
Nikkaji Number:J78.043J
Wikidata:Q83117271

Synonyms:8-((Diethylamino)methyl)-4'-fluoro-7-methoxy-3-methylflavone;86073-56-5;BRN 5997955;Flavone, 8-((diethylamino)methyl)-4'-fluoro-7-methoxy-3-methyl-;4H-1-Benzopyran-4-one, 8-((diethylamino)methyl)-2-(4-fluorophenyl)-7-methoxy-3-methyl-;8-[(Diethylamino)methyl]-4'-fluoro-7-methoxy-3-methylflavone;8-((Diethylamino)methyl)-2-(4-fluorophenyl)-7-methoxy-3-methyl-4H-chromen-4-one;8-[(diethylamino)methyl]-2-(4-fluorophenyl)-7-methoxy-3-methyl-4H-chromen-4-one;DTXSID10235381;LS-68963

Suppliers and Price of 8-((Diethylamino)methyl)-4'-fluoro-7-methoxy-3-methylflavone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of 8-((Diethylamino)methyl)-4'-fluoro-7-methoxy-3-methylflavone

Chemical Property:

Vapor Pressure:1.46E-09mmHg at 25°C
Boiling Point:485.1°C at 760 mmHg
PKA:9.20±0.25(Predicted)
Flash Point:247.2°C
PSA：42.68000
Density:1.172g/cm³
LogP:4.75790
XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:369.17402179
Heavy Atom Count:27
Complexity:552

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)CC1=C(C=CC2=C1OC(=C(C2=O)C)C3=CC=C(C=C3)F)OC

Technology Process of 8-((Diethylamino)methyl)-4'-fluoro-7-methoxy-3-methylflavone

There total 4 articles about 8-((Diethylamino)methyl)-4'-fluoro-7-methoxy-3-methylflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 86073-68-9
3-Methyl-7-methoxy-8-chloromethyl-4'-fluoroflavone

: 109-89-7
diethylamine

: 86073-56-5
3-Methyl-7-methoxy-8-diethyaminomethyl-4'-fluoroflavone

Guidance literature:: In benzene; for 48h; Ambient temperature;
DOI:10.1002/ardp.19833160507

Reference yield:

: 6270-44-6
2-hydroxy-4-methoxypropiophenone

: 86073-56-5
3-Methyl-7-methoxy-8-diethyaminomethyl-4'-fluoroflavone

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / sodium p-fluorobenzoate

2: 80 percent / HCl / acetic acid; aq. HCl / 5 h / 70 - 80 °C

3: 85 percent / benzene / 48 h / Ambient temperature

With hydrogenchloride; sodium 4-fluorobenzoate; In hydrogenchloride; acetic acid; benzene;
DOI:10.1002/ardp.19833160507

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 86073-56-5
3-Methyl-7-methoxy-8-diethyaminomethyl-4'-fluoroflavone

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / sodium p-fluorobenzoate

2: 80 percent / HCl / acetic acid; aq. HCl / 5 h / 70 - 80 °C

3: 85 percent / benzene / 48 h / Ambient temperature

With hydrogenchloride; sodium 4-fluorobenzoate; In hydrogenchloride; acetic acid; benzene;
DOI:10.1002/ardp.19833160507