N-(2-amino-4-methylphenyl)acetamide

Base Information

• Chemical Name: N-(2-amino-4-methylphenyl)acetamide
• CAS No.: 53476-34-9
• Molecular Formula: C9H12 N2 O
• Molecular Weight: 164.207
• Hs Code.: 2924299090
• NSC Number: 315540
• DSSTox Substance ID: DTXSID90317432
• Nikkaji Number: J153.403C
• Wikidata: Q82072182
• Mol file: 53476-34-9.mol

Synonyms:N-(2-amino-4-methylphenyl)acetamide;53476-34-9;4-Acetamido-3-aminotoluene;N1-(2-Amino-4-Methylphenyl)Acetamide;NSC315540;6-Acetylamino-m-toluidine;SCHEMBL9509772;DTXSID90317432;BBL002359;MFCD00047852;STK519559;AKOS000102658;NSC 315540;NSC-315540;VS-01054;CS-0217044;FT-0683239;EN300-67012;J-522861;Z274782976

Chemical Property of N-(2-amino-4-methylphenyl)acetamide

Chemical Property:

• Vapor Pressure: 2.71E-05mmHg at 25°C
• Boiling Point: 357.5°Cat760mmHg
• Flash Point: 170°C
• PSA: 55.12000
• Density: 1.163g/cm³
• LogP: 2.18980
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 164.094963011
• Heavy Atom Count: 12
• Complexity: 170

Purity/Quality:

98%min ^*data from raw suppliers

N-(2-Amino-4-methylphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)NC(=O)C)N

Technology Process of N-(2-amino-4-methylphenyl)acetamide

There total 7 articles about N-(2-amino-4-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-methyl-2-nitroacetanilide (612-45-3) → 2-amino-4-methylacetanilide (53476-34-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

Reference yield:

4-methyl-2-azidoacetanilide → 2-amino-4-methylacetanilide (53476-34-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; under 2585.7 Torr;

DOI:10.1021/jo00130a034

Reference yield:

4-methyl-2-nitroaniline (89-62-3) → 2-amino-4-methylacetanilide (53476-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethylmorpholine / diethyl ether

2: H₂ / Pd/C / acetic acid / 2585.7 Torr

With N-ethylmorpholine;; hydrogen; palladium on activated charcoal; In diethyl ether; acetic acid;

DOI:10.1021/jo00130a034

upstream raw materials:

4-methyl-2-nitroacetanilide

acetic acid

4-methyl-2-nitroaniline

Downstream raw materials:

2,5-dimethylbenzimidazole

4-methyl-1,2-diaminobenzene

3,4-diacetylaminotoluene

acetic acid-(2-benzylidenamino-4-methyl-anilide)