Lonaprofen

Base Information

Chemical Name:Lonaprofen
CAS No.:41791-49-5
Molecular Formula:C₁₄H₁₃ClO₃
Molecular Weight:264.708
Hs Code.:
European Community (EC) Number:255-555-3
UNII:4G86N0SVV3,J67595729X,E7HFC3GJC7
DSSTox Substance ID:DTXSID60866063
Nikkaji Number:J16.478J
Wikidata:Q106640732
NCI Thesaurus Code:C80561
ChEMBL ID:CHEMBL2105175
Mol file:41791-49-5.mol

Synonyms:Lonaprofen;41791-49-5;Lonaprofen [INN];Lonaprofene;Lonaprofeno;Lonaprofenum;Lonaprofen, (+)-;Lonaprofen, (-)-;E7HFC3GJC7;Lonaprofene [INN-French];Lonaprofenum [INN-Latin];methyl 2-(1-chloronaphthalen-2-yl)oxypropanoate;Lonaprofeno [INN-Spanish];UNII-4G86N0SVV3;4G86N0SVV3;Methyl 2-((1-chloro-2-naphthyl)oxy)propionate;EINECS 255-555-3;J67595729X;C14H13ClO3;(-)-Methyl 2-((1-chloro-2-naphthalenyl)oxy)propanoate;Propanoic acid, 2-((1-chloro-2-naphthalenyl)oxy)-, methyl ester, (+)-;Propanoic acid, 2-((1-chloro-2-naphthalenyl)oxy)-, methyl ester, (-)-;75186-77-5;75186-78-6;alpha-(1-Chloro-2-naphthyloxy)propionic acid, methyl ester;UNII-E7HFC3GJC7;SCHEMBL2109183;CHEMBL2105175;DTXSID60866063;UNII-J67595729X;(+)-METHYL 2-((1-CHLORO-2-NAPHTHALENYL)OXY)PROPANOATE;Propanoic acid, 2-((1-chloro-2-naphthalenyl)oxy)-, methyl ester

Suppliers and Price of Lonaprofen

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
LONAPROFEN 95.00%
5MG
$ 499.13

Total 4 raw suppliers

Chemical Property of Lonaprofen

Chemical Property:

Vapor Pressure:7.85E-06mmHg at 25°C
Boiling Point:375.3°Cat760mmHg
Flash Point:150.6°C
Density:1.243g/cm³
XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:264.0553220
Heavy Atom Count:18
Complexity:295

Purity/Quality:

99% ^*data from raw suppliers

LONAPROFEN 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(=O)OC)OC1=C(C2=CC=CC=C2C=C1)Cl

Technology Process of Lonaprofen

There total 2 articles about Lonaprofen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 30406-75-8
2-(naphthalen-2-yloxy)-propionic acid methyl ester

: 41791-49-5,75186-77-5,75186-78-6
methyl 2-(1-chloronaphth-2-yloxy)propionate

Guidance literature:: With tetraethylammonium chloride; trichloroacetonitrile; In acetonitrile; at 23 ℃; for 2h; Electrochemical reaction; Inert atmosphere;
DOI:10.1021/acs.orglett.1c00704

Reference yield:

: 135-19-3
β-naphthol

: 41791-49-5,75186-77-5,75186-78-6
methyl 2-(1-chloronaphth-2-yloxy)propionate

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2: trichloroacetonitrile; tetraethylammonium chloride / acetonitrile / 2 h / 23 °C / Electrochemical reaction; Inert atmosphere

With di-isopropyl azodicarboxylate; tetraethylammonium chloride; trichloroacetonitrile; triphenylphosphine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/acs.orglett.1c00704