2-(2-Naphthoxy)propionic acid methyl ester

Base Information

• Chemical Name: 2-(2-Naphthoxy)propionic acid methyl ester
• CAS No.: 30406-75-8
• Molecular Formula: C14H14 O3
• Molecular Weight: 230.263
• DSSTox Substance ID: DTXSID30952745
• Nikkaji Number: J490.838D
• Wikidata: Q27107493
• Metabolomics Workbench ID: 69682
• Mol file: 30406-75-8.mol

Synonyms:NOPM;2-(2-Naphthoxy)propionic acid methyl ester;30406-75-8;methyl 2-naphthalen-2-yloxypropanoate;Methyl 2-(2-naphthyloxy)propionate;Propanoic acid, 2-(2-naphthalenyloxy)-, methyl ester;2-(Naphthalen-2-yloxy)-propionic acid methyl ester;methyl 2-(2-naphthyloxy)propanoate;AC1L9E9W;ARONIS009992;methyl 2-(naphthalen-2-yloxy)propanoate;SureCN9579919;CHEBI:7441;SCHEMBL9579919;DTXSID30952745;MolPort-001-577-265;STK413621;AKOS000499171;AKOS016050651;Methyl 2-[(naphthalen-2-yl)oxy]propanoate;Q27107493

Chemical Property of 2-(2-Naphthoxy)propionic acid methyl ester

Chemical Property:

• Vapor Pressure: 5.58E-05mmHg at 25°C
• Boiling Point: 346.9°Cat760mmHg
• Flash Point: 144°C
• PSA: 35.53000
• Density: 1.145g/cm³
• LogP: 2.78010
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 230.094294304
• Heavy Atom Count: 17
• Complexity: 264

Purity/Quality:

methyl2-(2-naphthyloxy)propanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)OC)OC1=CC2=CC=CC=C2C=C1

Technology Process of 2-(2-Naphthoxy)propionic acid methyl ester

There total 5 articles about 2-(2-Naphthoxy)propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.4%

methanol (67-56-1) + 2-(Naphthalen-2-yloxy)-propionyl chloride (62782-37-0) → 2-(naphthalen-2-yloxy)-propionic acid methyl ester (30406-75-8)

Guidance literature:

In dichloromethane;

DOI:10.1016/j.tetasy.2005.07.009

Reference yield: 84.0%

methyl lactate (547-64-8,2155-30-8) + β-naphthol (135-19-3) → 2-(naphthalen-2-yloxy)-propionic acid methyl ester (30406-75-8)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c00704

Reference yield:

Methyl 2-bromopropionate (5445-17-0) + β-naphthol (135-19-3) → 2-(naphthalen-2-yloxy)-propionic acid methyl ester (30406-75-8)

Guidance literature:

With potassium carbonate; In acetonitrile; Reflux;

DOI:10.1016/j.bioorg.2022.105695

upstream raw materials:

methanol

2-(Naphthalen-2-yloxy)-propionyl chloride

methyl lactate

β-naphthol

Downstream raw materials:

(R)-2-(β-naphthyloxy)propionic acid

2-(2-naphthyloxy)propanoic acid

methyl 2-(1-chloronaphth-2-yloxy)propionate

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