N,N'-Ethylenedisalicylamide

Base Information

• Chemical Name: N,N'-Ethylenedisalicylamide
• CAS No.: 6345-72-8
• Molecular Formula: C16H16N2O4
• Molecular Weight: 300.314
• NSC Number: 43582
• DSSTox Substance ID: DTXSID30212871
• Nikkaji Number: J314.073C
• Wikidata: Q83088089
• ChEMBL ID: CHEMBL594783
• Mol file: 6345-72-8.mol

Synonyms:N,N'-Ethylenedisalicylamide;N,N'-Ethylenebis(salicylamide);6345-72-8;N,N'-Disalicyloylethylenediamine;N,N'-1,2-Ethanediylbis(2-hydroxybenzamide);BRN 2703123;CHEMBL594783;N,N'-Bis(2-hydroxybenzoyl)-1,2-diaminoethane;2-hydroxy-N-[2-[(2-hydroxybenzoyl)amino]ethyl]benzamide;Benzamide, N,N'-1,2-ethanediylbis(2-hydroxy-;2-hydroxy-N-{2-[(2-hydroxybenzoyl)amino]ethyl}benzamide;N,N'-ethane-1,2-diylbis(2-hydroxybenzamide);NSC43582;CBMicro_032037;Cambridge id 5762986;MixCom6_001701;N,N'-Ethylenebissalicylamide;MLS001209272;N,N'-Ethylenebissali-cylamide;SCHEMBL5707054;Salicylamide, N,N'-ethylenebis-;DTXSID30212871;HMS2832O22;1,2-bis(2-hydroxybenzamido)ethane;BDBM50481274;NSC 43582;NSC-43582;STK866938;AKOS000569156;1,2-Ethanediylbis(2-hydroxybenzamide);NCGC00245307-01;LS-26794;SMR000517008;BIM-0032179.P001;EU-0004740;Salicylamide, N,N'-ethylenebis- (7CI,8CI);AB00096131-01;N,N'-bis-(2-hydroxybenzoyl)-1,2-diaminoethane;2,2'-Dihydroxy-N,N'-(ethane-1,2-diyl)dibenzamide

Chemical Property of N,N'-Ethylenedisalicylamide

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 300.11100700
• Heavy Atom Count: 22
• Complexity: 352

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NCCNC(=O)C2=CC=CC=C2O)O

Technology Process of N,N'-Ethylenedisalicylamide

There total 15 articles about N,N'-Ethylenedisalicylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phenyl Salicylate (118-55-8) + ethylenediamine (107-15-3,85404-18-8) → N,N'-bis(2-hydroxybenzoyl)ethylenediamine (6345-72-8)

Guidance literature:

at 180 - 190 ℃; for 1h;

DOI:10.1021/ic501842x

Reference yield: 95.0%

ethylenediamine (107-15-3,85404-18-8) + methyl salicylate (119-36-8,8024-54-2) → N,N'-bis(2-hydroxybenzoyl)ethylenediamine (6345-72-8)

Guidance literature:

for 0.5h; Heating;

DOI:10.1055/s-1993-25893

Reference yield: 83.0%

ethylenediamine (107-15-3,85404-18-8) + methyl salicylate (119-36-8,8024-54-2) → N,N'-bis(2-hydroxybenzoyl)ethylenediamine (6345-72-8) + N-(2-aminoethyl)-2-hydroxybenzamide hydrochloride (92765-39-4)

Guidance literature:

In ethanol; at 100 ℃; for 2h;

upstream raw materials:

phenyl Salicylate

ethylenediamine

salicylic acid

methyl salicylate

Downstream raw materials:

1,2-bis(2-allyloxybenzoylamino)ethane

[Zn(1,2-bis(2-hydroxybenzamido)ethane^(2-))]

2-[(2-hydroxybenzoyl)amino]ethan-1-amine

salicylic acid