2-AMINO-4,6-DIMETHYL-3-PYRIDINECARBOXAMIDE

Base Information

• Chemical Name: 2-AMINO-4,6-DIMETHYL-3-PYRIDINECARBOXAMIDE
• CAS No.: 7144-20-9
• Molecular Formula: C8H11N3O
• Molecular Weight: 165.195
• Hs Code.: 29333999
• Mol file: 7144-20-9.mol

Synonyms:Nicotinamide,2-amino-4,6-dimethyl- (6CI,8CI);2-Amino-4,6-dimethylnicotinamide;NSC 73573;2-amino-4,6-dimethylpyridine-3-carboxamide;3-pyridinecarboxamide, 2-amino-4,6-dimethyl-;

Chemical Property of 2-AMINO-4,6-DIMETHYL-3-PYRIDINECARBOXAMIDE

Chemical Property:

• Appearance/Colour: Beige solid
• Vapor Pressure: 0.00776mmHg at 25°C
• Melting Point: 172-174 °C
• Refractive Index: 1.7400 (estimate)
• Boiling Point: 268.3 °C at 760 mmHg
• Flash Point: 116.1 °C
• PSA: 82.00000
• Density: 1.212 g/cm³
• LogP: 1.66100
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-4,6-dimethylnicotinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Amino-4,6-dimethylnicotinamide is used to prepare 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists.

Technology Process of 2-AMINO-4,6-DIMETHYL-3-PYRIDINECARBOXAMIDE

There total 4 articles about 2-AMINO-4,6-DIMETHYL-3-PYRIDINECARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

malonamamidine hydrochloride (34570-17-7) + acetylacetone (123-54-6,81235-32-7) → 2-Amino-4,6-dimethylnicotinamide (7144-20-9)

Guidance literature:

With potassium hydroxide; In methanol; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2017.06.050

Reference yield:

4,6-dimethyl-3-oxo-2,3-dihydro-1H-pyrazolo<3,4-b>pyridine (28491-67-0) → 2-Amino-4,6-dimethylnicotinamide (7144-20-9)

Guidance literature:

With ethanol; hydrogen; nickel;

DOI:10.1021/ja01519a043

Reference yield:

acetylacetone (123-54-6,81235-32-7) → 2-Amino-4,6-dimethylnicotinamide (7144-20-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH solution

2: ethanol; hydrogen; Raney nickel

With sodium hydroxide; ethanol; hydrogen; nickel;

DOI:10.1021/ja01519a043

upstream raw materials:

4,6-dimethyl-3-oxo-2,3-dihydro-1H-pyrazolo<3,4-b>pyridine

malonamamidine hydrochloride

acetylacetone

Downstream raw materials:

2-hydroxy-4,6-dimethylnicotinic acid

5,7-dimethyl-2-phenyl-2,3-dihydro-1H-pyrido[2,3-d][1,3,2]diazaborinin-4-one

C₁₆H₁₇N₃O₃

C₁₇H₁₇N₃O₃