Aminoacethydrazide

Base Information

• Chemical Name: Aminoacethydrazide
• CAS No.: 14379-80-7
• Molecular Formula: C2H7 N3 O
• Molecular Weight: 89.0971
• NSC Number: 516397
• UNII: FU2BH9M053
• DSSTox Substance ID: DTXSID70162548
• Nikkaji Number: J910.392I
• Wikidata: Q83031237
• ChEMBL ID: CHEMBL241347
• Mol file: 14379-80-7.mol

Synonyms:glycine hydrazide;glycine hydrazide monohydrobromide;glycine hydrazide sulfate

Chemical Property of Aminoacethydrazide

Chemical Property:

• Vapor Pressure: 8.72E-05mmHg at 25°C
• Boiling Point: 340.2°C at 760 mmHg
• Flash Point: 159.6°C
• Density: 1.19g/cm³
• XLogP3: -2.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 89.058911855
• Heavy Atom Count: 6
• Complexity: 52.8

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)NN)N

Technology Process of Aminoacethydrazide

There total 8 articles about Aminoacethydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) → aminoacetic acid hydrazide (14379-80-7)

Guidance literature:

N-(fluoren-9-ylmethoxycarbonyl)glycine; With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; dimethyl sulfoxide; for 2h;

With piperidine; In N,N-dimethyl-formamide; for 0.5h;

With trifluoroacetic acid; In water; for 2h;

DOI:10.1039/c5ob01404b

Reference yield:

Glycyl-L-leucine (869-19-2) + hydrazine (302-01-2,78206-91-4,119775-10-9,75013-58-0) → L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + aminoacetic acid hydrazide (14379-80-7)

Guidance literature:

at 125 ℃;

DOI:10.1038/178912b0 DOI:10.1246/bcsj.25.214

Reference yield:

GlyOEt*HCl (459-73-4) → aminoacetic acid hydrazide (14379-80-7)

Guidance literature:

With hydrazine hydrate;

upstream raw materials:

GlyOEt*HCl

glycine ethyl ester hydrochloride

hydrazine hydrate

Glycyl-L-leucine

Downstream raw materials:

C₁₆H₁₇N₅OS₂

glycine

4?phenyl?3?(phenylamino)?1H?1,2,4?triazole?5(4H)?thione

C₁₆H₁₅Br₂N₅OS₂

Refernces

• 1、 Bartolami, Eline,Bessin, Yannick,Bettache, Nadir,Gary-Bobo, Magali,Garcia, Marcel,Dumy, Pascal,Ulrich, Sébastien. "Multivalent DNA recognition by self-assembled clusters: deciphering structural effects by fragments screening and evaluation as siRNA vectors". . p. 9427 - 9438. Retrieved 2015.
• 2、 Mondal, Milon,Radeva, Nedyalka,Fanlo-Virgós, Hugo,Otto, Sijbren,Klebe, Gerhard,Hirsch, Anna K. H.. "Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial Chemistry". supporting information. p. 9422 - 9426. Retrieved 2016/08/05.
• 3、 Cave,Galons,Miocque,Rinjard,Tran,Binet. "Antihypertensive actions of hydrazidones: Study of acylated dichloroarylhydrazones". . p. 75 - 79. Retrieved 2007/10/02.