2-Aminoindan-1-ol

Base Information

• Chemical Name: 2-Aminoindan-1-ol
• CAS No.: 15028-16-7
• Molecular Formula: C9H11NO
• Molecular Weight: 149.192
• Hs Code.: 2922199090
• European Community (EC) Number: 239-107-4,819-277-1,874-882-8
• DSSTox Substance ID: DTXSID20933902
• Nikkaji Number: J238.891J
• Mol file: 15028-16-7.mol

Synonyms:2-Aminoindan-1-ol;2-amino-2,3-dihydro-1H-inden-1-ol;15028-16-7;13575-72-9;2-Amino-1-hydroxyindane;EINECS 239-107-4;cis-2-Amino-2,3-dihydro-1H-inden-1-ol;2-aminoindanol;23337-80-6;1H-Inden-1-ol, 2-amino-2,3-dihydro-;SCHEMBL1239152;DTXSID20933902;MFCD08544057;AKOS015899611;PS-4439;SB84176;SB84542;CS-0205434;FT-0660446;FT-0660447;FT-0660448;FT-0660449;FT-0660450;EN300-72088;A884175

Chemical Property of 2-Aminoindan-1-ol

Chemical Property:

• Melting Point: 171-172 °C
• Boiling Point: 296.9 °C at 760 mmHg
• PKA: 13.85±0.40(Predicted)
• Flash Point: 133.4 °C
• PSA: 46.25000
• Density: 1.212 g/cm³
• LogP: 1.30370
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 149.084063974
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-2,3-dihydro-1H-inden-1-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C(C2=CC=CC=C21)O)N

Technology Process of 2-Aminoindan-1-ol

There total 23 articles about 2-Aminoindan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-oximino-1-indanone (80070-34-4) → 2-amino-1-hydroxyindane (15028-16-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; water;

DOI:10.1016/S0040-4020(01)87039-3

Reference yield: 86.0%

indan-1,2-dione-2-oxime (15028-10-1) → 2-amino-1-hydroxyindane (15028-16-7)

Guidance literature:

With hydrogenchloride; hydrogen; In 1,4-dioxane; ethanol;

Reference yield: 16.0%

indan-1,2,3-trione hydrate (485-47-2) → 2-(Hydroxymethyliden)-1H-inden-1,3(2H)-dion (40461-93-6) + 2-amino-1-hydroxyindane (15028-16-7) + 2-aminoindane hydrochloride (2338-18-3)

Guidance literature:

indan-1,2,3-trione hydrate; With sulfuric acid; hydroxylamine hydrochloride; acetic acid; at 25 - 55 ℃; for 0.5h; Inert atmosphere;

With palladium 10% on activated carbon; hydrogen; under 2585.81 Torr; Inert atmosphere;

With hydrogenchloride; In pentan-1-ol; for 16h; Inert atmosphere;

DOI:10.1021/op000222h

upstream raw materials:

2-oximino-1-indanone

2-bromo-1-indanol

indan-1,2-dione-2-oxime

indan-1,2,3-trione hydrate

Downstream raw materials:

(-)-trans-1-Amino-indan-2-ol

N-(4-fluoro-3-methylphenyl)-3-[[(1S,2S)-1-hydroxyindan-2-yl]sulfamoyl]benzamide

N-(4-fluoro-3-methylphenyl)-3-[[(1R,2S)-1-hydroxyindan-2-yl]sulfamoyl]benzamide

N-(4-fluoro-3-methylphenyl)-3-[[(1R,2R)-1-hydroxyindan-2-yl]sulfamoyl]benzamide