2,3-dihydro-1H-inden-2-ylazanium;chloride

Base Information

• Chemical Name: 2,3-dihydro-1H-inden-2-ylazanium;chloride
• CAS No.: 2338-18-3
• Molecular Formula: C9H12ClN
• Molecular Weight: 169.654
• Hs Code.: 29214990
• Mol file: 2338-18-3.mol

Synonyms:AKOS023093343

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Chemical Property of 2,3-dihydro-1H-inden-2-ylazanium;chloride

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 0.0831mmHg at 25°C
• Melting Point: 245-247 °C(lit.)
• Boiling Point: 226.2 °C at 760 mmHg
• Flash Point: 96.8 °C
• PSA: 26.02000
• Density: 1.056 g/cm³
• LogP: 2.61480
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 169.0658271
• Heavy Atom Count: 11
• Complexity: 108

Purity/Quality:

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn:Harmful
• Statements: R22:
• Safety Statements: S22:; S24/25:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1C(CC2=CC=CC=C21)[NH3+].[Cl-]
• Description: Aminoindans (AI) were originally studied as semi-rigid congeners of phenylethylamines, which are psychoactive alkaloids. 2-AI is an aminoindane that serves as the starting point for the synthesis of psychoactive compounds, such as 5,6-methylenedioxy-2-aminoindane. 2-AI itself has modest analgesic and stimulatory properties. This product is intended for forensic applications.
• Uses: Prepared from 2-indanols via azide displacement and subsequent hydrogenation.

Technology Process of 2,3-dihydro-1H-inden-2-ylazanium;chloride

There total 11 articles about 2,3-dihydro-1H-inden-2-ylazanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-azido-2,3-dihydro-1H-indene (180260-72-4) → 2-aminoindane hydrochloride (2338-18-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; chloroform; at 25 ℃; for 20h;

DOI:10.1016/j.tet.2005.04.069

Reference yield: 91.0%

C17H17NO2 → 2-aminoindane hydrochloride (2338-18-3) + 4-methoxy-benzaldehyde (123-11-5)

Guidance literature:

C₁₇H₁₇NO₂; With 2-fluoropyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at 0 ℃; for 0.333333h;

With 1,1,3,3-Tetramethyldisiloxane; In dichloromethane; at 0 - 20 ℃; for 6.16667h;

With hydrogenchloride; In dichloromethane; water; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1007/s11426-016-0224-5

Reference yield: 88.0%

indan-1,2-dione-2-oxime (15028-10-1) → 2-aminoindane hydrochloride (2338-18-3)

Guidance literature:

indan-1,2-dione-2-oxime; With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 70 ℃; for 4h; Cooling with ice;

With hydrogenchloride; In ethyl acetate; pH=1 - 3;

upstream raw materials:

indan-2-yl-carbamic acid ethyl ester

indan-2-one oxime

2-azido-2,3-dihydro-1H-indene

indan-2-ol

Downstream raw materials:

5-bromo-2,3-dihydro-1H-inden-2-ylamine hydrochloride

2,3-dihydro-1H-inden-2-amine

{3-[2-(indan-2-ylaminomethyl)-4-trifluoromethyl-phenoxy]-phenyl}-acetic acid methyl ester

6-(4-amino-phenyl)-N⁴-indan-2-yl-pyrimidine-2,4-diamine