2-Amino-3,4,7,8-tetramethyl-3H-imidazo[4,5-F]quinoxaline

Base Information

• Chemical Name: 2-Amino-3,4,7,8-tetramethyl-3H-imidazo[4,5-F]quinoxaline
• CAS No.: 132898-07-8
• Molecular Formula: C₁₃H₁₅N₅
• Molecular Weight: 241.296
• DSSTox Substance ID: DTXSID40157840
• Nikkaji Number: J505.526A
• Wikidata: Q83026002
• Mol file: 132898-07-8.mol

Synonyms:132898-07-8;2-Amino-3,4,7,8-tetramethyl-3H-imidazo[4,5-F]quinoxaline;4,7,8-Trimeiqx;4,7,8-Trimethyl-IQX;CCRIS 6409;3,4,7,8-tetramethylimidazo[4,5-f]quinoxalin-2-amine;3H-Imidazo(4,5-f)quinoxalin-2-amine, 3,4,7,8-tetramethyl-;2-Amino-3,4,7,8-tetramethylimidazo(4,5-f)quinoxaline;3,4,7,8-Tetramethyl-3H-imidazo(4,5-f)quinoxalin-2-amine;3,4,7,8-TETRAMETHYL-3H-IMIDAZO[4,5-F]QUINOXALIN-2-AMINE;3H-Imidazo[4,5-f]quinoxalin-2-amine, 3,4,7,8-tetramethyl-;2-AMINO-3,4,7,8-TETRAMETHYLIMIDAZO[4,5-F]QUINOXALINE;SCHEMBL9473191;DTXSID40157840;AKOS030255820;LS-80540;FT-0662074;FT-0662075;J-006245

Chemical Property of 2-Amino-3,4,7,8-tetramethyl-3H-imidazo[4,5-F]quinoxaline

Chemical Property:

• Vapor Pressure: 5.49E-09mmHg at 25°C
• Melting Point: >250℃
• Refractive Index: 1.6500 (estimate)
• Boiling Point: 469.5°Cat760mmHg
• PKA: 2.85±0.50(Predicted)
• Flash Point: 237.7°C
• PSA: 69.62000
• Density: 1.38g/cm³
• LogP: 2.60510
• Storage Temp.: Refrigerator
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 241.13274550
• Heavy Atom Count: 18
• Complexity: 323

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3,4,7,8-tetramethyl-3H-imidazo[4,5-f]quinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=NC(=C(N=C2C3=C1N(C(=N3)N)C)C)C
• Uses: Mutagenic imidazoquinoxaline. Mutagenic chemical in bacterial systems (Ames test) as well as being active in the DNA repair test in liver cells

Technology Process of 2-Amino-3,4,7,8-tetramethyl-3H-imidazo[4,5-F]quinoxaline

There total 7 articles about 2-Amino-3,4,7,8-tetramethyl-3H-imidazo[4,5-F]quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-5-methylbenzene-1,2-diamine (63155-04-4) → 2-amino-3,4,7,8-tetramethylimidazo[4,5-f]quinoxaline (132898-07-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 88 percent / aq. HCl, SeO₂ / 80 °C

2: 56 percent / conc. H₂SO₄, conc. HNO₃ / 1 h / 0 - 20 °C

3: 82 percent / 2-methoxy-ethanol; H₂O / 0.17 h / Heating

4: 40percent aq. NH₄SH / methanol / 3 h / Heating

5: methanol; H₂O / 3 h / Heating

6: H₂ / Raney nickel / aq. ethanol / 1 h / Ambient temperature

7: aq. ethanol / 5 °C

With hydrogenchloride; selenium(IV) oxide; ammonium sulfide; sulfuric acid; hydrogen; nitric acid; nickel; In methanol; ethanol; 2-methoxy-ethanol; water;

Reference yield:

5-chloro-6-methyl-2,1,3-benzoselenadiazole (2255-94-9) → 2-amino-3,4,7,8-tetramethylimidazo[4,5-f]quinoxaline (132898-07-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 56 percent / conc. H₂SO₄, conc. HNO₃ / 1 h / 0 - 20 °C

2: 82 percent / 2-methoxy-ethanol; H₂O / 0.17 h / Heating

3: 40percent aq. NH₄SH / methanol / 3 h / Heating

4: methanol; H₂O / 3 h / Heating

5: H₂ / Raney nickel / aq. ethanol / 1 h / Ambient temperature

6: aq. ethanol / 5 °C

With ammonium sulfide; sulfuric acid; hydrogen; nitric acid; nickel; In methanol; ethanol; 2-methoxy-ethanol; water;

Reference yield:

5-chloro-6-methyl-4-nitro-2,1,3-benzoselenadiazole (147021-84-9) → 2-amino-3,4,7,8-tetramethylimidazo[4,5-f]quinoxaline (132898-07-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 82 percent / 2-methoxy-ethanol; H₂O / 0.17 h / Heating

2: 40percent aq. NH₄SH / methanol / 3 h / Heating

3: methanol; H₂O / 3 h / Heating

4: H₂ / Raney nickel / aq. ethanol / 1 h / Ambient temperature

5: aq. ethanol / 5 °C

With ammonium sulfide; hydrogen; nickel; In methanol; ethanol; 2-methoxy-ethanol; water;

upstream raw materials:

bromocyane

4-chloro-5-methylbenzene-1,2-diamine

5-chloro-6-methyl-2,1,3-benzoselenadiazole

5-chloro-6-methyl-4-nitro-2,1,3-benzoselenadiazole

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