N-(4-1H-imidazol-1-yl)butyl-2-(1-methylethyl)-11-oxo-11H-pyrido(2,1b)quinazoline-8-carboxamide

Base Information

Chemical Name:N-(4-1H-imidazol-1-yl)butyl-2-(1-methylethyl)-11-oxo-11H-pyrido(2,1b)quinazoline-8-carboxamide
CAS No.:88939-84-8
Molecular Formula:C₂₃H₂₅N₅O₂
Molecular Weight:403.484
Hs Code.:
Mol file:88939-84-8.mol

Synonyms:N-(4-1H-imidazol-1-yl)butyl-2-(1-methylethyl)-11-oxo-11H-pyrido(2,1b)quinazoline-8-carboxamide

Suppliers and Price of N-(4-1H-imidazol-1-yl)butyl-2-(1-methylethyl)-11-oxo-11H-pyrido(2,1b)quinazoline-8-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of N-(4-1H-imidazol-1-yl)butyl-2-(1-methylethyl)-11-oxo-11H-pyrido(2,1b)quinazoline-8-carboxamide

Chemical Property:

PSA：84.78000
Density:1.27g/cm³
LogP:3.95260

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(4-1H-imidazol-1-yl)butyl-2-(1-methylethyl)-11-oxo-11H-pyrido(2,1b)quinazoline-8-carboxamide

There total 10 articles about N-(4-1H-imidazol-1-yl)butyl-2-(1-methylethyl)-11-oxo-11H-pyrido(2,1b)quinazoline-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.8%

: 201230-82-2
carbon monoxide

: 107962-04-9
N-<4-(1H-imidazol-1-yl)butyl>-6-<<2-bromo-4-(1-methylethyl)phenyl>amino>-3-pyridinecarboxamide

: 88939-84-8
N-<4-(1H-imidazol-1-yl)butyl>-2-(1-methylethyl)-11-oxo-11H-pyrido<2,1-b>quinazoline-8-carboxamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; tributyl-amine; triphenylphosphine; In water; N,N-dimethyl-formamide; at 100 ℃; for 12h; under 10343 Torr;
DOI:10.1021/jo00388a023

Reference yield: 87.0%

: 88941-01-9
2-(1-methylethyl)-11-oxo-11H-pyrido<2,1-b>quinazoline-8-carboxylic acid cyanomethyl ester

: 67319-76-0
4-(1H-imidazol-1-yl)butanamine

: 88939-84-8
N-<4-(1H-imidazol-1-yl)butyl>-2-(1-methylethyl)-11-oxo-11H-pyrido<2,1-b>quinazoline-8-carboxamide

Guidance literature:: In N,N-dimethyl-formamide; at 35 ℃; for 18h;
DOI:10.1021/jm00384a031

Reference yield:

: 72338-63-7
4-imidazol-1-ylbutyronitrile

: 88939-84-8
N-<4-(1H-imidazol-1-yl)butyl>-2-(1-methylethyl)-11-oxo-11H-pyrido<2,1-b>quinazoline-8-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / Et₃N, H₂ / Raney cobalt / methanol / 3 h / 100 - 110 °C / 62057.8 Torr

2: 87 percent / dimethylformamide / 18 h / 35 °C

With hydrogen; triethylamine; cobalt; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00384a031