Lansoprazole sulfide

Base Information Edit

Chemical Name:Lansoprazole sulfide
CAS No.:103577-40-8
Molecular Formula:C16H14F3N3OS
Molecular Weight:353.368
Hs Code.:29309090
European Community (EC) Number:600-451-9,692-135-2
UNII:58XP950E2T
DSSTox Substance ID:DTXSID60145906
Nikkaji Number:J354.391I
Wikidata:Q27261628
Pharos Ligand ID:2KZ7YAUFJGKC
ChEMBL ID:CHEMBL899
Mol file:103577-40-8.mol

Synonyms:103577-40-8;LANSOPRAZOLE SULFIDE;2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole;AG-1777;2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methylthio-1H-benzimidazole;H 225/18;K-1252;Lansoprazole impurity C [EP];UNII-58XP950E2T;1H-Benzimidazole, 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)thio)-;EC 600-451-9;58XP950E2T;LANSOPRAZOLE SULPHIDE COMPOUND;2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]thio]-1H-benzimidazole;2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfanyl]-1H-benzimidazole;2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]sulphanyl]-1H-benzimidazole;2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)thio)-1H-benzimidazole;2-(3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methylthio-1h-benzimidazole;AG 1777;SMR000119917;CHEMBL899;MLS000122531;LANSOPRAZOLE IMPURITY C;SCHEMBL106519;DTXSID60145906;HMS2365G10;BCP12346;MFCD00834357;AKOS000676433;AB07398;AC-1232;CS-W013902;2-[[(3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDINYL)METHYL]THIO]-1H-BENZIMIDAZOLE;2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methylsulfanyl]-1H-benzimidazole;2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl ]methyl thio-1H-benzimidazole;AS-13211;FT-0631026;LANSOPRAZOLE IMPURITY C [EP IMPURITY];M2800;F19518;Q-200222;Q27261628;2-[[3-Methyl-4-(2,2,2-trifluoroethoxy)pyrid-2-yl]methylthio]benzimidazole;2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylmethylthio]benzimidazole;2-((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methylthio)-1H-benzo[d]imidazole;2-([3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]-methyl)thio-1H-benzimidazole;2-({[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl}sulfanyl)-1H-1,3-benzodiazole;2-[[[3 methyl-4-(2,2,2 trifluoroethoxy) 2-pyridyl]-methyl] thio]-1H-benzimidazole;2-[[[3-methyl-4-(2,2,2-trifluoro-ethoxy)-2-pyridinyl]methyl]-thio]1H-benzimidazole;2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]-methyl]thio]-1H-benzimidazole;2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]thio]-1h-benzimidazol;2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]thio]benzimidazole;2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]-methyl]thio]benzimidazole;2-[[[3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)-2-PYRIDYL]METHYL]THIO]BENZIMIDAZOLE;2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methylthio]-1H-benzimidazole;2-[3-methyl-4-(2,2,2-trifluoro ethoxy)-2-pyridyl]methylthio-1H-benzimidazole;2-[3-Methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethylsulfanyl]-1H-benzoimidazole;2-[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methylthio-1H-benzimidazole;2-{[3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylthio}-1H-benzimidazole

Suppliers and Price of Lansoprazole sulfide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Lansoprazole Sulfide
100mg
$ 403.00

TRC
LansoprazoleSulfide
500mg
$ 600.00

TRC
LansoprazoleSulfide
50mg
$ 80.00

TCI Chemical
2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylmethylthio]benzimidazole >98.0%(HPLC)(T)
5g
$ 247.00

TCI Chemical
2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylmethylthio]benzimidazole >98.0%(HPLC)(T)
1g
$ 50.00

Medical Isotopes, Inc.
LansoprazoleSulfide
0.5 g
$ 1760.00

Medical Isotopes, Inc.
LansoprazoleSulfide
100 mg
$ 845.00

Matrix Scientific
2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole 95+%
1g
$ 98.00

Matrix Scientific
2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole 95+%
5g
$ 335.00

Crysdot
2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole 97%
5g
$ 339.00

Total 132 raw suppliers

Chemical Property of Lansoprazole sulfide Edit

Chemical Property:

Appearance/Colour:pale yellow solid
Vapor Pressure:6.2E-10mmHg at 25°C
Melting Point:149-150 °C
Refractive Index:1.615
Boiling Point:494.9 °C at 760 mmHg
PKA:10.60±0.10(Predicted)
Flash Point:253.1 °C
PSA：76.10000
Density:1.41 g/cm³
LogP:4.49970
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:353.08096774
Heavy Atom Count:24
Complexity:413

Purity/Quality:

99%, ^*data from raw suppliers

Lansoprazole Sulfide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=CN=C1CSC2=NC3=CC=CC=C3N2)OCC(F)(F)F
Uses A metabolite of Lansoprazole, as gastric pump inhibitor Lansoprazole Sulfide (Lansoprazole EP Impurity C; USP Impurity B) is a metabolite of Lansoprazole, as gastric pump inhibitor.

Technology Process of Lansoprazole sulfide

There total 10 articles about Lansoprazole sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

: 3-methyl-4-(2,2,2-trifluoroethoxy)-2-chloromethylpyridine hydrochloride

: 134469-07-1
Benzimidazol-2-thiol

: 103577-40-8
lansoprazole sulfide

Guidance literature:: With sodium hydroxide; In methanol; water; at 10 - 35 ℃; for 4h;

Reference yield: 97.1%

: 128430-66-0
2-(chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine

: 134469-07-1
Benzimidazol-2-thiol

: 103577-40-8
lansoprazole sulfide

Guidance literature:: With sodium hydroxide; In water; Flow reactor;
DOI:10.1021/op300325f

Reference yield: 80.0%

: 103577-45-3
lansoprasole

: 103577-40-8
lansoprazole sulfide

Guidance literature:: With 1,2,3-trimethoxybenzene; oxalyl dichloride; In chloroform; at 0 ℃; for 0.00166667h; chemoselective reaction; Inert atmosphere;
DOI:10.1002/chem.202001815