2-(Chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine

Base Information

• Chemical Name: 2-(Chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine
• CAS No.: 128430-66-0
• Molecular Formula: C9H9ClF3NO
• Molecular Weight: 239.625
• Hs Code.: 2933399090
• UNII: T5V9XP53ZV
• DSSTox Substance ID: DTXSID70351036
• Nikkaji Number: J350.364J
• Wikidata: Q82127129
• Mol file: 128430-66-0.mol

Synonyms:128430-66-0;2-(chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine;2-CHLOROMETHYL-3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDINE;2-Chloromethyl-3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridine;T5V9XP53ZV;pyridine, 2-(chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)-;UNII-T5V9XP53ZV;SCHEMBL4392912;2-CHLOROMETHYL-3-METHYL-4-TRIFLUOROETHYLPYRIDINE;DTXSID70351036;AENYCMZUDXQARW-UHFFFAOYSA-N;BCP12952;BBL007595;MFCD03001422;STK801349;AKOS005612973;SB32640;VS-01684;CS-0444311;FT-0608753;EN300-1268633;AN-829/25073009

Chemical Property of 2-(Chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine

Chemical Property:

• Appearance/Colour: Light yellow liquid
• Melting Point: 112-116?°C(lit.)
• Boiling Point: 259.055 °C at 760 mmHg
• PKA: 4.41±0.30(Predicted)
• Flash Point: 110.473 °C
• PSA: 22.12000
• Density: 1.306 g/cm³
• LogP: 3.06990
• Storage Temp.: 2-8°C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 239.0324761
• Heavy Atom Count: 15
• Complexity: 200

Purity/Quality:

97% ^*data from raw suppliers

2-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CN=C1CCl)OCC(F)(F)F
• Uses: 2-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine is a reactant in the synthesis of benzimidazole core drugs such as lansoprazole(L175000), pantoprazole(P183000), and rabeprazole(R070500).

Technology Process of 2-(Chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine

There total 4 articles about 2-(Chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine (103577-66-8) → 2-(chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine (128430-66-0)

Guidance literature:

With thionyl chloride; In 1,4-dioxane; at 50 ℃; for 3h;

Reference yield: 84.6%

6-(chloromethyl)-5-methyl-4-(2,2,2-trifluoroethoxy)-2,3,4,5-tetrahydropyridine → 2-(chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine (128430-66-0)

Guidance literature:

With dihydrogen peroxide; C₂₂H₁₈MnN₂O₅; In ethanol; at 30 ℃; for 5h; Reagent/catalyst; Solvent;

Reference yield:

2,3-dimethyl-4-(2,2,2-trifluoroethoxy)-pyridine N-oxide (103577-61-3) → 2-(chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine (128430-66-0)

Guidance literature:

2,3-dimethyl-4-(2,2,2-trifluoroethoxy)-pyridine N-oxide; With p-toluenesulfonyl chloride; In toluene; at 50 ℃; for 0.5h;

With triethylamine; In toluene; at 65 ℃; for 1.5h;

DOI:10.1081/SCC-120003612

upstream raw materials:

2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine

2,3-dimethyl-4-(2,2,2-trifluoroethoxy)-pyridine N-oxide

2-acetoxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine

Downstream raw materials:

lansoprazole sulfide

2-chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine-1-oxide

C₄₉H₃₈F₃N₇OS

C₁₅H₁₃F₄NO

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 128430-66-0 2-CHLOROMETHYL-3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDINE

Send

Send

Metric Ton KG G Pound L ML

Send

Send