128430-66-0

Basic information

• Product Name: 2-CHLOROMETHYL-3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDINE
• Synonyms: 2-CHLOROMETHYL-3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDINE;Pyridine, 2-(chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)-;2-Chloromethyl-3-methyl-4-trifluoroethylpyridine;2-Chloromethyl-3-methyl-4-(2,2,2-trifluoro-ethoxy);2-CHLOROMETHYL-3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDINE 99+% (HPLC)
• CAS NO: 128430-66-0
• Molecular Formula: C₉H₉ClF₃NO
• Molecular Weight: 239.62
• Product Categories: Lansoprazole
• Mol File: 128430-66-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 259.055 °C at 760 mmHg
• Flash Point: 110.473 °C
• Appearance: Light yellow liquid
• Density: 1.306 g/cm³
• Storage Temp.: 2-8°C
• PKA: 4.41±0.30(Predicted)
• CAS DataBase Reference: 2-CHLOROMETHYL-3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROMETHYL-3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDINE(128430-66-0)
• EPA Substance Registry System: 2-CHLOROMETHYL-3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDINE(128430-66-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 128430-66-0(Hazardous Substances Data)

Usage

Uses

2-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine is a reactant in the synthesis of benzimidazole core drugs such as lansoprazole(L175000), pantoprazole(P183000), and rabeprazole(R070500).

Upstream product

• 112525-75-4 2-acetoxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine 
• 103577-61-3 2,3-dimethyl-4-(2,2,2-trifluoroethoxy)-pyridine N-oxide 
• 103577-66-8 2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine 

Downstream Products

• 103577-45-3 lansoprasole 
• 1416422-96-2 C₁₅H₁₃F₄NO 
• 1247013-54-2 C₄₉H₃₈F₃N₇OS 
• 163119-28-6 2-chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine-1-oxide 
• 103577-40-8 lansoprazole sulfide 

Relevant articles and documents

Preparation method of lansoprazole key intermediate

The invention relates to a preparation method of a lansoprazole key intermediate. According to the technical scheme, the preparation method comprises the following steps: firstly, respectively preparing (2, 2, 2-trifluoroethoxy)ethylene (a compound 7) and 3-amino-4-chloro-2-methylbut-2-enoic acid ethyl ester (a compound 9); and then reacting the compound 7 with the compound 9 to prepare 6-(chloromethyl)-5-methyl-4-(2, 2, 2-trifluoroethoxy)-2,3,4,5- tetrahydropyridine; finally, oxidizing 6-(chloromethyl)-5-methyl-4-(2, 2, 2-trifluoroethoxy)-2, 3, 4, 5-tetrahydropyridine (compound 10) by hydrogen peroxide under the catalytic action of Mn(O)-Salon to generate 2-(chloromethyl)-3-methyl-4-(2, 2, 2-trifluoroethoxy)pyridine (compound 5). According to the technical scheme, danger is reduced, energy consumption is reduced, and the method is more suitable for large-scale industrial production.

A practical one pot synthesis of 2-[2-(pridylmethyl)-thio]-1H-benzimidazoles

A combination of Et3N and pTSCl was found to be far superior than pTSCl or benzene sulfonyl chloride alone in convert ing substituted 2-picoline-N-oxides to the corresponding 2-chloromethylpyridines and has been exploited for the synthesis of a variety of 2-[2-(pyridylmethyl)-thio]-1H-benzimidazoles, key intermediates in the manufacture of H+/K+-ATPase inhibitors in a single pot.