N,N-Dimethyl-m-(trifluoromethyl)cinnamamide

Base Information

• Chemical Name: N,N-Dimethyl-m-(trifluoromethyl)cinnamamide
• CAS No.: 93040-63-2
• Molecular Formula: C12H12F3NO
• Molecular Weight: 243.229
• ChEMBL ID: CHEMBL104029
• Nikkaji Number: J3.292.424G
• Wikidata: Q76327086

Synonyms:BRN 6510026;N,N-Dimethyl-m-(trifluoromethyl)cinnamamide;CINNAMAMIDE, N,N-DIMETHYL-m-(TRIFLUOROMETHYL)-;93040-63-2;CHEMBL104029

Chemical Property of N,N-Dimethyl-m-(trifluoromethyl)cinnamamide

Chemical Property:

• Vapor Pressure: 7.63E-05mmHg at 25°C
• Boiling Point: 342.2°C at 760 mmHg
• Flash Point: 160.8°C
• Density: 1.208g/cm³
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 243.08709849
• Heavy Atom Count: 17
• Complexity: 297

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C(=O)C=CC1=CC(=CC=C1)C(F)(F)F
• Isomeric SMILES: CN(C)C(=O)/C=C/C1=CC(=CC=C1)C(F)(F)F

Technology Process of N,N-Dimethyl-m-(trifluoromethyl)cinnamamide

There total 6 articles about N,N-Dimethyl-m-(trifluoromethyl)cinnamamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-(trifluoromethyl)cinnamic acid (779-89-5,67801-07-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → (E)-N,N-dimethyl-3-[3-(trifluoromethyl)phenyl]acrylamide (93040-63-2)

Guidance literature:

With hydrogenchloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In 1,4-dioxane; at 120 ℃; for 4h;

DOI:10.1055/s-0035-1561427

Reference yield: 97.0%

trans-3-(trifluoromethyl)cinnamoyl chloride (60689-14-7,64379-91-5) + dimethyl amine (124-40-3) → (E)-N,N-dimethyl-3-[3-(trifluoromethyl)phenyl]acrylamide (93040-63-2)

Guidance literature:

In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jm00379a007

Reference yield: 82.0%

3-(trifluoromethyl)benzyl alcohol (349-75-7) + N,N-dimethyl acetamide (127-19-5,116057-81-9) → (E)-N,N-dimethyl-3-[3-(trifluoromethyl)phenyl]acrylamide (93040-63-2)

Guidance literature:

With Eosin Y; potassium hydroxide; at 20 ℃; Irradiation;

DOI:10.1039/c8ob02938e

upstream raw materials:

trans-3-(trifluoromethyl)cinnamoyl chloride

dimethyl amine

N,N-Dimethylacrylamide

m-trifluoromethylphenyl iodide

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