2(S)-Amino-4-azido-butanoic Acid

Base Information

• Chemical Name: 2(S)-Amino-4-azido-butanoic Acid
• CAS No.: 120042-14-0
• Molecular Formula: C4H8N4O2
• Molecular Weight: 144.133
• Mol file: 120042-14-0.mol

Synonyms:Butanoicacid, 2-amino-4-azido-, (S)-;

Chemical Property of 2(S)-Amino-4-azido-butanoic Acid

Chemical Property:

• Appearance/Colour: off-white solid
• Melting Point: 220-223 °C
• PSA: 113.07000
• LogP: 0.25176
• Storage Temp.: -20°C Freezer
• Solubility.: Water

Purity/Quality:

97% ^*data from raw suppliers

2(S)-Amino-4-azido-butanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: L-azidohomoalaine provides a fast, sensitive, non-toxic and non-radioactive alternative to the traditional radioactive technique, 35S-methionine for the detection of nascent protein. L-azidohomoalaine is an amino acid analog that contains a small modification and its azido moiety can be fed to cultured cells and incorporated into proteins during active protein synthesis.
• Uses: A novel mutagenic amino acid 2(S)-Amino-4-azido-butanoic Acid is a novel mutagenic amino acid.

Technology Process of 2(S)-Amino-4-azido-butanoic Acid

There total 5 articles about 2(S)-Amino-4-azido-butanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-benzyl 4-azido-2-(tert-butoxycarbonylamino)butanoate (1224702-09-3) → (2S)-2-amino-4-azidobutanoic acid (120042-14-0)

Guidance literature:

With boron tribromide; In dichloromethane; at -10 - 20 ℃; for 3.08333h; Inert atmosphere;

DOI:10.1055/S-0029-1218391

Reference yield: 47.0%

C12H21BN4O2 → (2S)-2-amino-4-azidobutanoic acid (120042-14-0)

Guidance literature:

With ethylenediamine; In tetrahydrofuran; for 2h; Reflux;

DOI:10.1002/anie.201003325

Reference yield:

methyl (2S)-4-bromo-2-[(tert-butoxycarbonyl)amino]butanoate (76969-87-4) → (2S)-2-amino-4-azidobutanoic acid (120042-14-0)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 22h; Inert atmosphere;

DOI:10.1016/j.ejmech.2020.112451

upstream raw materials:

(2S)-2-amino-4-azidobutanoic acid methyl ester

(S)-benzyl 4-azido-2-(tert-butoxycarbonylamino)butanoate

O-acetyl-L-homoserine

methyl (2S)-4-bromo-2-[(tert-butoxycarbonyl)amino]butanoate

Downstream raw materials:

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-azidobutanoic acid

DL-methionine

β-cyano-L-alanine