Ethyl N-((2-hydroxyphenyl)methyl)glycinate

Base Information

• Chemical Name: Ethyl N-((2-hydroxyphenyl)methyl)glycinate
• CAS No.: 57938-78-0
• Molecular Formula: C11H15 N O3
• Molecular Weight: 209.245
• European Community (EC) Number: 261-025-2
• DSSTox Substance ID: DTXSID30206639
• Nikkaji Number: J296.832K
• Wikidata: Q83080491
• Mol file: 57938-78-0.mol

Synonyms:57938-78-0;Ethyl N-((2-hydroxyphenyl)methyl)glycinate;ethyl 2-[(2-hydroxyphenyl)methylamino]acetate;EINECS 261-025-2;ETHYL N-[(2-HYDROXYPHENYL)METHYL]GLYCINATE;ETHYL 2-{[(2-HYDROXYPHENYL)METHYL]AMINO}ACETATE;SCHEMBL6240662;DTXSID30206639;Ethyl2-((2-hydroxybenzyl)amino)acetate;Ethyl 2-((2-hydroxybenzyl)amino)acetate;N-(2-Hydroxyphenylmethyl)glycine ethyl ester;EN300-255928

Chemical Property of Ethyl N-((2-hydroxyphenyl)methyl)glycinate

Chemical Property:

• Vapor Pressure: 0.000113mmHg at 25°C
• Boiling Point: 326.5°C at 760 mmHg
• Flash Point: 151.3°C
• PSA: 58.56000
• Density: 1.146g/cm³
• LogP: 1.43580
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 209.10519334
• Heavy Atom Count: 15
• Complexity: 196

Purity/Quality:

97% ^*data from raw suppliers

EthylN-((2-hydroxyphenyl)methyl)glycinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CNCC1=CC=CC=C1O

Technology Process of Ethyl N-((2-hydroxyphenyl)methyl)glycinate

There total 4 articles about Ethyl N-((2-hydroxyphenyl)methyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

glycine ethyl ester hydrochloride (623-33-6) + salicylaldehyde (90-02-8) → N-(2-hydroxybenzyl)glycine ethyl ester (57938-78-0)

Guidance literature:

glycine ethyl ester hydrochloride; salicylaldehyde; With potassium hydroxide; In methanol; ethanol; at 20 ℃; for 2h;

With methanol; sodium tetrahydroborate; In ethanol; at 20 ℃; for 0.25h;

With sodium tetrahydroborate; acetic acid; In methanol; ethanol; pH=4; Further stages.;

DOI:10.1039/b709293h

Reference yield:

salicylaldehyde (90-02-8) → N-(2-hydroxybenzyl)glycine ethyl ester (57938-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; magnesium sulfate / dichloromethane / 1 h / 20 °C

1.2: 36 h / 20 °C

2.1: sodium tetrahydroborate / methanol; dichloromethane / 3 h

With sodium tetrahydroborate; magnesium sulfate; triethylamine; In methanol; dichloromethane;

DOI:10.1007/s11164-012-0973-3

Reference yield:

ethyl N-salicylideneglycinate (66949-73-3) → N-(2-hydroxybenzyl)glycine ethyl ester (57938-78-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; dichloromethane; for 3h;

DOI:10.1007/s11164-012-0973-3

upstream raw materials:

glycine ethyl ester hydrochloride

salicylaldehyde

ethyl N-salicylideneglycinate

Downstream raw materials:

N-(2-hydroxybenzyl)-glycinamide

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