Ethyl 2-(2,5-dichlorothiophen-3-yl)-2-oxoacetate

Base Information

Chemical Name:Ethyl 2-(2,5-dichlorothiophen-3-yl)-2-oxoacetate
CAS No.:32766-64-6
Molecular Formula:C8H6 Cl2 O3 S
Molecular Weight:253.106
Hs Code.:2934999090
DSSTox Substance ID:DTXSID30407144
Mol file:32766-64-6.mol

Synonyms:32766-64-6;ethyl 2-(2,5-dichlorothiophen-3-yl)-2-oxoacetate;ethyl (2,5-dichlorothien-3-yl)(oxo)acetate;ethyl 2,5-dichloro-3-thienylglyoxylate;SCHEMBL7042846;DTXSID30407144;IZEPVHXRDFHYNR-UHFFFAOYSA-N;AKOS000118221;CS-0308887;EN300-13834;3-(2-TRIFLUOROMETHYL-PHENYL)-ACRYLOYLCHLORIDE;Z94598478;(2,5-Dichlorothiophen-3-yl)-oxo-acetic acid ethyl ester;ETHYL (2,5-DICHLOROTHIOPHEN-3-YL)(OXO)ACETATE

Suppliers and Price of Ethyl 2-(2,5-dichlorothiophen-3-yl)-2-oxoacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl2-(2,5-dichlorothiophen-3-yl)-2-oxoacetate 95+%
1g
$ 339.00

Chemenu
ethyl2-(2,5-dichlorothiophen-3-yl)-2-oxoacetate 95%
1g
$ 320.00

Arctom
Ethyl2-(2,5-dichlorothiophen-3-yl)-2-oxoacetate 95%
1g
$ 431.00

American Custom Chemicals Corporation
ETHYL (2,5-DICHLOROTHIEN-3-YL)(OXO)ACETATE 95.00%
5G
$ 1548.26

American Custom Chemicals Corporation
ETHYL (2,5-DICHLOROTHIEN-3-YL)(OXO)ACETATE 95.00%
2.5G
$ 1227.82

American Custom Chemicals Corporation
ETHYL (2,5-DICHLOROTHIEN-3-YL)(OXO)ACETATE 95.00%
1G
$ 852.55

Alichem
Ethyl2-(2,5-dichlorothiophen-3-yl)-2-oxoacetate
1g
$ 400.00

Total 5 raw suppliers

Chemical Property of Ethyl 2-(2,5-dichlorothiophen-3-yl)-2-oxoacetate

Chemical Property:

Vapor Pressure:9.08E-05mmHg at 25°C
Boiling Point:339.6°Cat760mmHg
Flash Point:159.2°C
PSA：71.61000
Density:1.481g/cm³
LogP:2.80070
Storage Temp.:2-8°C
XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:251.9414706
Heavy Atom Count:14
Complexity:247

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-(2,5-dichlorothiophen-3-yl)-2-oxoacetate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(=O)C1=C(SC(=C1)Cl)Cl

Technology Process of Ethyl 2-(2,5-dichlorothiophen-3-yl)-2-oxoacetate

There total 2 articles about Ethyl 2-(2,5-dichlorothiophen-3-yl)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 3172-52-9,173777-89-4
2,5-diclorothiophene

: 4755-77-5
Ethyl oxalyl chloride

: 32766-64-6
ethyl 2,5-dichloro-3-thienylglyoxylate

Guidance literature:: With aluminium trichloride; In nitromethane; 1.) 10 deg C, 1 h, 2.) room temp., 1 h;
DOI:10.1002/ardp.19893221115

Reference yield:

: 32766-64-6
ethyl 2,5-dichloro-3-thienylglyoxylate

Guidance literature:: 2,5-Dichlorthiophen, Ethyloxyoxalylchlorid, AlCl3;

Reference yield:

: 32766-64-6
ethyl 2,5-dichloro-3-thienylglyoxylate

: 58414-52-1
thiophen-3-yl-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 34 percent / KOH, N₂H₄*H₂O; aq. HCl / H₂O / 2 h / Heating

2: 90 percent / diethyl ether

3: 18 percent Chromat. / H2, NaBH4 / Pd / dimethylformamide / 3.33 h / 50 °C / 760 Torr / Pd on γ-aminopropyl-silica gel; other acceptor of HCl

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; hydrogen; hydrazine hydrate; palladium; In diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1007/BF00505952