2,3-Dichlorofluorobenzene

Base Information

• Chemical Name: 2,3-Dichlorofluorobenzene
• CAS No.: 36556-50-0
• Molecular Formula: C6H3Cl2F
• Molecular Weight: 164.994
• Hs Code.: 2903999090
• European Community (EC) Number: 670-879-9
• DSSTox Substance ID: DTXSID9067986
• Nikkaji Number: J195.816J
• Wikidata: Q72466208
• Mol file: 36556-50-0.mol

Synonyms:2,3-Dichlorofluorobenzene;36556-50-0;1,2-Dichloro-3-fluorobenzene;Benzene, dichlorofluoro-;Benzene, 1,2-dichloro-3-fluoro-;2,3-dichloro-1-fluorobenzene;2,3-dichloro-4-fluorobenzene;MFCD00060647;dichloro-fluorobenzene;SCHEMBL530880;1,6-Dichloro-2-fluorobenzene;1-Fluoro-2,3-dichlorobenzene;1,2-Dichloro-3-fluoro-benzene;DTXSID9067986;1,2-Dichloro-3-fluorobenzene #;CK2390;AKOS006229007;AC-26082;BS-22420;CS-0059220;FT-0609565;A20566

Chemical Property of 2,3-Dichlorofluorobenzene

Chemical Property:

• Boiling Point: 175.8 °C at 760 mmHg
• Flash Point: 61 °C
• PSA: 0.00000
• Density: 1.404 g/cm³
• LogP: 3.13250
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 163.9595836
• Heavy Atom Count: 9
• Complexity: 97.1

Purity/Quality:

98%min ^*data from raw suppliers

2,3-Dichlorofluorobenzene 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)Cl)Cl)F

Technology Process of 2,3-Dichlorofluorobenzene

There total 6 articles about 2,3-Dichlorofluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2,3-dichlorobenzenediazonium hexafluorophosphate → 2,3-dichlorofluorobenzene (36556-50-0)

Guidance literature:

With boron trifluoride diethyl etherate; at -10 - 5 ℃; for 4h; Irradiation;

DOI:10.1080/00397919308011253

Reference yield: 45.0%

2,3-dichlorobenzeneboronic acid (151169-74-3) → 2,3-dichlorofluorobenzene (36556-50-0)

Guidance literature:

With acetyl hypofluorite; In acetic acid; acetonitrile; at 0 - 20 ℃; for 0.166667h;

DOI:10.1021/jo401832f

Reference yield: 1.0%

1,2,3-trichlorobenzene (87-61-6) → 1,2,3-trifluorobenzene (1489-53-8) + 1,3-dichloro-2-fluorobenzene (2268-05-5) + 2,3-dichlorofluorobenzene (36556-50-0) + 3-chloro-1,2-difluorobenzene (36556-47-5) + 1-chloro-2,6-difluorobenzene (38361-37-4)

Guidance literature:

With potassium fluoride; In various solvent(s); at 290 ℃; for 12h; Product distribution; reaction carried out in a bomb; variation of temperature, time and solvent, CsF as reagent;

DOI:10.1016/S0022-1139(00)80961-6

upstream raw materials:

1,2,3-trichlorobenzene

2,3-dichlorobenzeneboronic acid

Downstream raw materials:

2,3-dichloro-1-fluoro-4-nitrobenzene

1-(2,3-dichlorophenyl)piperazine hydrochloride

3,4-dichloro-2-fluorobenzaldehyde

1-(2,3-dichlorophenyl)-piperazine hydrochloride

Refernces

• 1、 Shinhama,Aki,Furuta,Minamikawa. "Facile conversion of arenediazonium salts to the corresponding fluoroarenes using boron trifluoride diethyl ether complex". . p. 1577 - 1582. Retrieved 2007/10/02.
• 2、 Pews, R. Garth,Gall, James A.. "AROMATIC FLUORINE CHEMISTRY. PART 5. PREPARATION OF 2,6-DIFLUOROANILINE AND 1,2-DIFLUOROBENZENE". . p. 379 - 386. Retrieved 2007/10/02.