4'-hydroxyflurbiprofen

Base Information

Chemical Name:4'-hydroxyflurbiprofen
CAS No.:52807-12-2
Molecular Formula:C₁₅H₁₃FO₃
Molecular Weight:260.265
Hs Code.:2922299090
Mol file:52807-12-2.mol

Synonyms:4`-Hydroxy Flurbiprofen;2-(2-fluoro-4'-hydroxy-4-biphenylyl)propionic acid;2-(2-fluoro-4'-hydroxy-biphenyl-4-yl)-propionic acid;2-(2-fluoro-4'-hydroxybiphenyl-4-yl)propanoic acid;2-(4'-Hydroxy-2-fluoro-4-biphenylyl)propionic Acid;FPH;

Suppliers and Price of 4'-hydroxyflurbiprofen

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4’-HydroxyFlurbiprofen
25mg
$ 850.00

TRC
4’-HydroxyFlurbiprofen
5mg
$ 185.00

Cayman Chemical
4'-hydroxy Flurbiprofen
1mg
$ 71.00

Cayman Chemical
4'-hydroxy Flurbiprofen
5mg
$ 317.00

Cayman Chemical
4'-hydroxy Flurbiprofen
10mg
$ 562.00

American Custom Chemicals Corporation
4'-HYDROXY FLURBIPROFEN 95.00%
50MG
$ 1963.50

American Custom Chemicals Corporation
4'-HYDROXY FLURBIPROFEN 95.00%
5MG
$ 786.50

AK Scientific
4'-Hydroxyflurbiprofen
5mg
$ 495.00

AK Scientific
4'-Hydroxyflurbiprofen
1mg
$ 187.00

Total 8 raw suppliers

Chemical Property of 4'-hydroxyflurbiprofen

Chemical Property:

Melting Point:177-178°C
Boiling Point:417.6°Cat760mmHg
PKA:4.20±0.10(Predicted)
Flash Point:206.3°C
PSA：57.53000
Density:1.288g/cm³
LogP:3.38640
Storage Temp.:-20°C Freezer

Purity/Quality:

99% ^*data from raw suppliers

4’-HydroxyFlurbiprofen ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 4'-hydroxyflurbiprofen is a metabolite of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.

Technology Process of 4'-hydroxyflurbiprofen

There total 12 articles about 4'-hydroxyflurbiprofen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

: 215175-84-1
methyl 2-(4′-acetoxy-2-fluoro-[1,1′-biphenyl]-4-yl)propanoate

: 52807-12-2
2-(2-fluoro-4'-hydroxy-biphenyl-4-yl)-propionic acid

Guidance literature:: With potassium hydroxide; In methanol; water; for 2h; Reflux;
DOI:10.1016/j.bmc.2019.01.040

Reference yield:

: 446-35-5
2,4-Difluoronitrobenzene

: 52807-12-2
2-(2-fluoro-4'-hydroxy-biphenyl-4-yl)-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylsulfoxide / 15 °C

1.2: 87 percent / dimethylsulfoxide / 0.5 h / 15 °C

2.1: 95 percent / H₂ / Pd/C / ethanol / 1 h / atmospheric pressure

3.1: aq. HCl; NaNO₂ / 0 °C

3.2: aq. KI / 3 h / 0 - 20 °C

4.1: 58 percent / aq. NaOH / ethanol / 8 h / 100 °C

5.1: aq. Na₂CO₃; Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 80 °C

With hydrogenchloride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium hydride; sodium carbonate; sodium nitrite; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; dimethyl sulfoxide; 5.1: Suzuki coupling;
DOI:10.1021/jm0502541

Reference yield:

: 78543-06-3
diethyl 2-(3-fluoro-4-nitrophenyl)-2-methyl-malonate

: 52807-12-2
2-(2-fluoro-4'-hydroxy-biphenyl-4-yl)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / H₂ / Pd/C / ethanol / 1 h / atmospheric pressure

2.1: aq. HCl; NaNO₂ / 0 °C

2.2: aq. KI / 3 h / 0 - 20 °C

3.1: 58 percent / aq. NaOH / ethanol / 8 h / 100 °C

4.1: aq. Na₂CO₃; Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 80 °C

With hydrogenchloride; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium carbonate; sodium nitrite; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; 4.1: Suzuki coupling;
DOI:10.1021/jm0502541