2-(4'-Acetoxy-2-fluoro-biphenyl-4-YL)-propionic acid methyl ester

Base Information

• Chemical Name: 2-(4'-Acetoxy-2-fluoro-biphenyl-4-YL)-propionic acid methyl ester
• CAS No.: 215175-84-1
• Molecular Formula: C₁₈H₁₇FO₄
• Molecular Weight: 316.329
• DSSTox Substance ID: DTXSID70595635
• Mol file: 215175-84-1.mol

Synonyms:215175-84-1;2-(4'-ACETOXY-2-FLUORO-BIPHENYL-4-YL)-PROPIONIC ACID METHYL ESTER;methyl 2-[4-(4-acetyloxyphenyl)-3-fluorophenyl]propanoate;Methyl 2-(4'-Acetoxy-2-fluoro-biphenyl-4-yl)-propionate;Methyl 2-(4'-acetoxy-2-fluoro-[1,1'-biphenyl]-4-yl)propanoate;Methyl 2-(4'-Acetoxy-2-fluoro-biphenyl-4-yl)-propionate-d3;starbld0019056;SCHEMBL8195056;DTXSID70595635;AKOS030255524;AB66044;DB-354799;A935762;J-014122;Methyl 2-(4'-acetoxy-2-fluoro-4-biphenylyl)propanoate;Methyl 2-[4'-(acetyloxy)-2-fluoro[1,1'-biphenyl]-4-yl]propanoate;2-(4 inverted exclamation mark -Acetoxy-2-fluoro-biphenyl-4-yl)-propionic Acid Methyl Ester

Chemical Property of 2-(4'-Acetoxy-2-fluoro-biphenyl-4-YL)-propionic acid methyl ester

Chemical Property:

• Boiling Point: 401.2 °C at 760 mmHg
• Flash Point: 189.6 °C
• PSA: 52.60000
• Density: 1.186 g/cm³
• LogP: 3.69450
• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 316.11108718
• Heavy Atom Count: 23
• Complexity: 417

Purity/Quality:

98%min ^*data from raw suppliers

2-(4’-Acetoxy-2-fluoro-biphenyl-4-yl)-propionicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC(=C(C=C1)C2=CC=C(C=C2)OC(=O)C)F)C(=O)OC

Technology Process of 2-(4'-Acetoxy-2-fluoro-biphenyl-4-YL)-propionic acid methyl ester

There total 4 articles about 2-(4'-Acetoxy-2-fluoro-biphenyl-4-YL)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 2-(4'-acetyl-2-fluoro-[1,1'-biphenyl]-4-yl)propanoate (215175-83-0) → methyl 2-(4′-acetoxy-2-fluoro-[1,1′-biphenyl]-4-yl)propanoate (215175-84-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 24h; Reflux;

DOI:10.1016/j.bmc.2019.01.040

Reference yield:

fluorobiprofen (5104-49-4) → methyl 2-(4′-acetoxy-2-fluoro-[1,1′-biphenyl]-4-yl)propanoate (215175-84-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 3 h / Reflux

2: aluminum (III) chloride / dichloromethane / Reflux

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 20 °C

With aluminum (III) chloride; sulfuric acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 2: |Friedel-Crafts Acylation / 3: |Baeyer-Villiger Ketone Oxidation;

DOI:10.1016/j.bmcl.2013.04.008

Reference yield:

methyl 2-(2-fluoro-4-biphenylyl)propionate (113544-38-0,113544-39-1,114376-61-3,66202-86-6) → methyl 2-(4′-acetoxy-2-fluoro-[1,1′-biphenyl]-4-yl)propanoate (215175-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / dichloromethane / Reflux

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 20 °C

With aluminum (III) chloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 1: |Friedel-Crafts Acylation / 2: |Baeyer-Villiger Ketone Oxidation;

DOI:10.1016/j.bmcl.2013.04.008 DOI:10.1016/j.bmc.2013.03.005

upstream raw materials:

fluorobiprofen

methyl 2-(2-fluoro-4-biphenylyl)propionate

methyl 2-(4'-acetyl-2-fluoro-[1,1'-biphenyl]-4-yl)propanoate

Downstream raw materials:

2-(2-fluoro-4'-hydroxy-biphenyl-4-yl)-propionic acid

4-{2'-fluoro-4'-[1-oxo-1-(3-(1,2,3,4-tetrahydroacridin-9-ylamino)propylamino)propan-2-yl]biphenyl-4-yloxy}butyl nitrate

6-{2'-fluoro-4'-[1-oxo-1-(3-(1,2,3,4-tetrahydroacridin-9-ylamino)propylamino)propan-2-yl]biphenyl-4-yloxy}hexyl nitrate

2-{2'-fluoro-4'-[1-oxo-1-(4-(1,2,3,4-tetrahydroacridin-9-ylamino)butylamino)propan-2-yl]biphenyl-4-yloxy}ethyl nitrate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 215175-84-1 Methyl 2-(4’-Acetoxy-2-fluoro-biphenyl-4-yl)-propionate

Send

Send

Metric Ton KG G Pound L ML

Send

Send