Bisindolylmaleimide v

Base Information

Chemical Name:Bisindolylmaleimide v
CAS No.:113963-68-1
Molecular Formula:C21H15N3O2
Molecular Weight:341.3627
Hs Code.:2933990090
European Community (EC) Number:601-289-1
DSSTox Substance ID:DTXSID50150620
Nikkaji Number:J442.994J
Wikidata:Q72446081
Metabolomics Workbench ID:94441
ChEMBL ID:CHEMBL291725
Mol file:113963-68-1.mol

Synonyms:2,3-bis(indol-3-yl)-N-methylmaleimide;bisindolylmaleimide V

Suppliers and Price of Bisindolylmaleimide v

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Bisindolylmaleimide V
1mg
$ 295.00

TRC
1-Methyl-3,4-bis(3-indolyl)maleimide
100mg
$ 65.00

SynChem
1-Methyl-3,4-bis(3-indolyl)maleimide 95+%
1 g
$ 500.00

SynChem
1-Methyl-3,4-bis(3-indolyl)maleimide 95+%
5 g
$ 2000.00

Sigma-Aldrich
Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem
250ug
$ 55.70

Sigma-Aldrich
Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem
1mg
$ 181.00

Matrix Scientific
1-Methyl-3,4-bis(3-indolyl)maleimide 95+%
1g
$ 998.00

Chemenu
3,4-Di(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione 95%
1g
$ 371.00

Cayman Chemical
Bisindolylmaleimide V ≥98%
25mg
$ 893.00

Cayman Chemical
Bisindolylmaleimide V ≥98%
10mg
$ 408.00

Total 28 raw suppliers

Chemical Property of Bisindolylmaleimide v

Chemical Property:

Appearance/Colour:Red solid.
Vapor Pressure:0mmHg at 25°C
Melting Point:>260 °C
Refractive Index:1.794
Boiling Point:655.691 °C at 760 mmHg
PKA:15.89±0.30(Predicted)
Flash Point:350.349 °C
PSA：68.96000
Density:1.451 g/cm³
LogP:3.49650
Storage Temp.:−20°C
Solubility.:DMSO: soluble
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:341.116426730
Heavy Atom Count:26
Complexity:604

Purity/Quality:

97% ^*data from raw suppliers

Bisindolylmaleimide V ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=O)C(=C(C1=O)C2=CNC3=CC=CC=C32)C4=CNC5=CC=CC=C54
Description Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1?Does not inhibit PKC (at concentrations <100?mM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2?such as GF 109203X3?and other structurally related inhibitors4.

Technology Process of Bisindolylmaleimide v

There total 24 articles about Bisindolylmaleimide v which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1123-61-1
3,4-dichloro-1-methyl-pyrrole-2,5-dione

: indolylmagnesium bromide

: 113963-68-1
bisindolylmaleimide V

Guidance literature:: In toluene;
DOI:10.1016/j.bmcl.2005.04.015

Reference yield: 94.0%

: 119139-20-7
3-(1H-indol-3-yl)-4-[1-{tert-butyloxycarbonyl}indol-3-yl]-1-methyl-1H-pyrrole-2,5-dione

: 113963-68-1
bisindolylmaleimide V

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 8h; Heating;
DOI:10.1016/S0040-4039(01)02225-0

Reference yield: 89.0%

: 119139-23-0
3,4-bis(3-indolyl)-1H-pyrrole-2,5-dione

: 74-88-4
methyl iodide

: 113963-68-1
bisindolylmaleimide V

Guidance literature:: 3,4-bis(3-indolyl)-1H-pyrrole-2,5-dione; With potassium hydroxide; In acetone; at 0 ℃; for 0.5h;

methyl iodide; In acetone; at 0 - 20 ℃;
DOI:10.1016/j.cclet.2017.08.019