(9S)-6,7,10,11-tetrahydro-9-[(triphenylmethoxy)methyl]-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]-oxadiazacyclohexadecine-18,20(19H)-dione

Base Information

• Chemical Name: (9S)-6,7,10,11-tetrahydro-9-[(triphenylmethoxy)methyl]-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]-oxadiazacyclohexadecine-18,20(19H)-dione
• CAS No.: 170277-76-6
• Molecular Formula: C₄₅H₃₇N₃O₄
• Molecular Weight: 683.806
• Mol file: 170277-76-6.mol

Synonyms:(9S)-6,7,10,11-tetrahydro-9-[(triphenylmethoxy)methyl]-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]-oxadiazacyclohexadecine-18,20(19H)-dione

Chemical Property of (9S)-6,7,10,11-tetrahydro-9-[(triphenylmethoxy)methyl]-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]-oxadiazacyclohexadecine-18,20(19H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (9S)-6,7,10,11-tetrahydro-9-[(triphenylmethoxy)methyl]-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]-oxadiazacyclohexadecine-18,20(19H)-dione

There total 5 articles about (9S)-6,7,10,11-tetrahydro-9-[(triphenylmethoxy)methyl]-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]-oxadiazacyclohexadecine-18,20(19H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(9S)-6,7,10,11-tetrahydro-9-[(triphenylmethoxy)methyl]-5,21:12,17-dimetheno-9H-dibenzo[e,k]furo[3,4-h][1,4,13]-oxadiazacyclohexadecine-18,20-dione (170277-75-5) → (9S)-6,7,10,11-tetrahydro-9-[(triphenylmethoxy)methyl]-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]-oxadiazacyclohexadecine-18,20(19H)-dione (170277-76-6)

Guidance literature:

With methanol; 1,1,1,3,3,3-hexamethyl-disilazane; In N,N-dimethyl-formamide; at 80 ℃; for 7h; other reagents: NH₄OH, NH₄OAc;

DOI:10.1021/jo971980h

Reference yield: 82.0%

1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) + (9S)-6,7,10,11-tetrahydro-9-[(triphenylmethoxy)methyl]-5,21:12,17-dimetheno-9H-dibenzo[e,k]furo[3,4-h][1,4,13]-oxadiazacyclohexadecine-18,20-dione (170277-75-5) → (9S)-6,7,10,11-tetrahydro-9-[(triphenylmethoxy)methyl]-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]-oxadiazacyclohexadecine-18,20(19H)-dione (170277-76-6)

Guidance literature:

In methanol; N,N-dimethyl-formamide; at 80 ℃; for 5h;

DOI:10.1021/acschemneuro.8b00196

Reference yield:

C45H36N2O6(2-)*2K(1+) → (9S)-6,7,10,11-tetrahydro-9-[(triphenylmethoxy)methyl]-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]-oxadiazacyclohexadecine-18,20(19H)-dione (170277-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 17.7 g / citric acid / CH₂Cl₂; H₂O

2: 97 percent / hexamethyldisilazane, methanol / dimethylformamide / 7 h / 80 °C / other reagents: NH₄OH, NH₄OAc

With methanol; 1,1,1,3,3,3-hexamethyl-disilazane; citric acid; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo971980h

upstream raw materials:

(9S)-6,7,10,11-tetrahydro-9-[(triphenylmethoxy)methyl]-5,21:12,17-dimetheno-9H-dibenzo[e,k]furo[3,4-h][1,4,13]-oxadiazacyclohexadecine-18,20-dione

bisindolylmaleimide V

(9S)-6,7,10,11-tetrahydro-19-methyl-9-[(triphenylmethoxy)-methyl]-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h]-[1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione

1,1,1,3,3,3-hexamethyl-disilazane

Downstream raw materials:

Ruboxistaurin mesylate