6-ETHYL-5-(4-NITRO-PHENYL)-PYRIMIDINE-2,4-DIAMINE

Base Information

• Chemical Name: 6-ETHYL-5-(4-NITRO-PHENYL)-PYRIMIDINE-2,4-DIAMINE
• CAS No.: 71552-34-6
• Molecular Formula: C12H13 N5 O2
• Molecular Weight: 259.268
• Hs Code.: 2933599090
• Mol file: 71552-34-6.mol

Synonyms:Pyrimidine,2,4-diamino-6-ethyl-5-(p-nitrophenyl)- (6CI);6-Ethyl-5-(4-nitrophenyl)-2,4-pyrimidinediamine; NSC 372954

Chemical Property of 6-ETHYL-5-(4-NITRO-PHENYL)-PYRIMIDINE-2,4-DIAMINE

Chemical Property:

• Vapor Pressure: 7.2E-12mmHg at 25°C
• Boiling Point: 543.4°C at 760 mmHg
• Flash Point: 282.4°C
• PSA: 123.64000
• Density: 1.361g/cm³
• LogP: 3.46420
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly, Heated), DMSO (Slightly, Heated)

Purity/Quality:

99% ^*data from raw suppliers

6-Ethyl-5-(4-nitrophenyl)-2,4-pyrimidinediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A diaminopyrimidine derivative with antimalarial and antibacterial properties.

Technology Process of 6-ETHYL-5-(4-NITRO-PHENYL)-PYRIMIDINE-2,4-DIAMINE

There total 10 articles about 6-ETHYL-5-(4-NITRO-PHENYL)-PYRIMIDINE-2,4-DIAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

6-ethyl-5-phenylpyrimidine-2,4-diamine (27653-49-2) → 6-ethyl-5-(4'-nitrophenyl)-pyrimidine-2,4-diamine (71552-34-6)

Guidance literature:

With sulfuric acid; nitric acid; at 0 - 20 ℃; for 2h;

DOI:10.1081/SCC-120024725

Reference yield: 27.0%

2-(4-nitrophenyl)-3-oxopentanenitrile (848665-64-5) + guanidine hydrochloride (50-01-1) → 6-ethyl-5-(4'-nitrophenyl)-pyrimidine-2,4-diamine (71552-34-6)

Guidance literature:

2-(4-nitrophenyl)-3-oxopentanenitrile; With diazomethane; In ethyl acetate;

guanidine hydrochloride; With potassium ethoxide; In ethanol; for 2h; Heating / reflux;

Reference yield: 27.0%

2-(4-nitrophenyl)-3-oxopentanenitrile (848665-64-5) + potassium ethoxide (917-58-8) + guanidine hydrochloride (50-01-1) → 6-ethyl-5-(4'-nitrophenyl)-pyrimidine-2,4-diamine (71552-34-6)

Guidance literature:

With CYANAMID; In diethyl ether; ethanol; ethyl acetate; for 2h; Heating / reflux;

upstream raw materials:

6-ethyl-5-phenylpyrimidine-2,4-diamine

(Z)-3-Methoxy-2-(4-nitro-phenyl)-pent-2-enenitrile

guanidine hydrochloride

2-(4-nitrophenyl)-3-oxopentanenitrile

Downstream raw materials:

5-(4'-aminophenyl)-6-ethyl-pyrimidine-2,4-diamine

6-Ethyl-5-[4-(4-methanesulfonyl-benzylamino)-phenyl]-pyrimidine-2,4-diamine

1-(4-{[4-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-phenylamino]-methyl}-phenyl)-ethanone

Refernces

• 1、 -. "Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists". Page/Page column 26. . Retrieved 2010/02/13.
• 2、 Holsworth, Daniel D.,Stier, Michael,Edmunds, Jeremy J.,He, Wei,Place, Samuel,Maiti, Samarendra. "An expeditious synthesis of 6-alkyl-5-(4′ -amino-phenyl)-pyrimidine-2,4-diamines". . p. 3467 - 3475. Retrieved 2007/10/03.