4-Formamidobenzoic acid

Base Information

• Chemical Name: 4-Formamidobenzoic acid
• CAS No.: 28533-43-9
• Molecular Formula: C8H7 N O3
• Molecular Weight: 165.148
• Hs Code.: 2924299090
• NSC Number: 30096
• DSSTox Substance ID: DTXSID60283150
• Nikkaji Number: J1.148.484K
• Wikidata: Q82017616
• Mol file: 28533-43-9.mol

Synonyms:4-formamidobenzoic acid;28533-43-9;4-Formamido Benzoic Acid;4-(formylamino)benzoic acid;Benzoic acid, 4-(formylamino)-;4-FormamidoBenzoicAcid;NSC30096;p-Formamidebenzoic acid;N-formyl p-aminobenzoic acid;SCHEMBL1086165;YSZC2167;DTXSID60283150;NSC-30096;AKOS009157426;CS-W017891;AS-75966;FT-0668802;EN300-90264;D95548;AE-562/41868375;J-017115;Z760037024

Chemical Property of 4-Formamidobenzoic acid

Chemical Property:

• Vapor Pressure: 4.14E-08mmHg at 25°C
• Boiling Point: 428.6°Cat760mmHg
• Flash Point: 213°C
• PSA: 66.40000
• Density: 1.39g/cm³
• LogP: 1.66200
• Storage Temp.: Refrigerator
• Solubility.: DMSO, Methanol
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 165.042593085
• Heavy Atom Count: 12
• Complexity: 173

Purity/Quality:

≥99% ^*data from raw suppliers

4-Formamidobenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)O)NC=O
• Uses: 4-Formamido Benzoic Acid (cas# 28533-43-9) is a compound useful in organic synthesis.

Technology Process of 4-Formamidobenzoic acid

There total 12 articles about 4-Formamidobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) + formyl acetic anhydride (2258-42-6) → 4-formamidobenzoic acid (28533-43-9)

Guidance literature:

In dichloromethane; for 12h;

DOI:10.3390/molecules26185686

Reference yield: 95.0%

formic acid (64-18-6) + 4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 4-formamidobenzoic acid (28533-43-9)

Guidance literature:

With sodium formate; at 20 ℃; for 4h; Neat (no solvent);

DOI:10.1016/j.tetlet.2010.02.119

Reference yield: 93.0%

formic acid (64-18-6) + 4-nitro-benzoic acid (62-23-7) → 4-formamidobenzoic acid (28533-43-9)

Guidance literature:

With palladium(II) trifluoroacetate; triphenylphosphine; In water; at 80 ℃; for 1h; Sealed tube; Green chemistry;

DOI:10.1007/s00706-017-2071-0

upstream raw materials:

formic acid

4-amino-benzoic acid

N,N-dimethyl-formamide

Methyl formate

Downstream raw materials:

4-formylamino-3-nitro-benzoic acid

4-Formylamino-benzoic acid 4-((R)-1-hexyloxy-ethyl)-phenyl ester

4-Formylamino-benzoic acid 4-((R)-1-methyl-heptyloxy)-phenyl ester

4-Formylamino-benzoic acid 4-((R)-1-butoxycarbonyl-ethoxy)-phenyl ester