Multi-step reaction with 10 steps
1: 1-hydroxybenzotriazole, N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 24 h / Ambient temperature
2: pyridine / CH2Cl2 / 12 h / 0 - 20 °C
3: K2CO3, tetrabutylammonium iodide / dimethylsulfoxide / 4 h / 70 °C
4: hydroxyammonium chloride, aq. AcONa / ethanol / 1.5 h / 60 °C
5: formic acid, H2 / 10percent Pd/C / methanol / 3 h / 760 Torr
6: ethanol / 24 h / 80 °C
7: 0.4 M aq. LiOH / dioxane / 16 h / Ambient temperature
8: 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine, N-ethyl-N'-(3-(dimethylamino)propyl)carbodiimide hydrochloride / tetrahydrofuran / 120 h / Ambient temperature
9: 18percent aq. HCl / dioxane
10: 1.) pyridine, 2.) pyridine / 1.) toluol, dichloromethane, 0 deg C, 2.) toluol, dichloromethane, RT, 16 h
With
pyridine; hydrogenchloride; lithium hydroxide; formic acid; hydroxylamine hydrochloride; hydrogen; sodium acetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm950641i