1-Ethyl-4-(3,4,5-trimethoxyphenyl)-1-(2-thienyl)-N,N-dimethylbutylamine

Base Information

Chemical Name:1-Ethyl-4-(3,4,5-trimethoxyphenyl)-1-(2-thienyl)-N,N-dimethylbutylamine
CAS No.:120656-45-3
Molecular Formula:C₂₁H₃₁NO₃S
Molecular Weight:377.548
Hs Code.:
DSSTox Substance ID:DTXSID70923510

Synonyms:120656-45-3;1-Ethyl-4-(3,4,5-trimethoxyphenyl)-1-(2-thienyl)-N,N-dimethylbutylamine;2-Thiophenemethanamine, N,N-dimethyl-alpha-ethyl-alpha-(3-(3,4,5-trimethoxyphenyl)propyl)-;N,N-Dimethyl-alpha-ethyl-alpha-(3-(3,4,5-trimethoxyphenyl)propyl)-2-thiophenemethanamine;C21H31NO3S;SCHEMBL9799232;DTXSID70923510;IRVSXFXWSUCMQE-UHFFFAOYSA-N;C21-H31-N-O3-S;LS-153110;N,N-Dimethyl-3-(thiophen-2-yl)-6-(3,4,5-trimethoxyphenyl)hexan-3-amine

Suppliers and Price of 1-Ethyl-4-(3,4,5-trimethoxyphenyl)-1-(2-thienyl)-N,N-dimethylbutylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 1-Ethyl-4-(3,4,5-trimethoxyphenyl)-1-(2-thienyl)-N,N-dimethylbutylamine

Chemical Property:

Vapor Pressure:4.64E-09mmHg at 25°C
Boiling Point:471.5°C at 760 mmHg
Flash Point:238.9°C
Density:1.073g/cm³
XLogP3:4.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:377.20246502
Heavy Atom Count:26
Complexity:395

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(CCCC1=CC(=C(C(=C1)OC)OC)OC)(C2=CC=CS2)N(C)C

Technology Process of 1-Ethyl-4-(3,4,5-trimethoxyphenyl)-1-(2-thienyl)-N,N-dimethylbutylamine

There total 4 articles about 1-Ethyl-4-(3,4,5-trimethoxyphenyl)-1-(2-thienyl)-N,N-dimethylbutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 120656-44-2
1-ethyl-4-(3,4,5-trimethoxyphenyl)-1-(thien-2-yl)-N-methylbutylamine

: 120656-45-3
1-ethyl-4-(3,4,5-trimethoxyphenyl)-1-(thien-2-yl)-N,N-dimethylbutylamine

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; In methanol; for 2h; Yield given; Ambient temperature;
DOI:10.1248/cpb.44.1168

Reference yield:

: 110406-98-9
3-(3,4,5-trimethoxyphenyl)propyl chloride

: 120656-45-3
1-ethyl-4-(3,4,5-trimethoxyphenyl)-1-(thien-2-yl)-N,N-dimethylbutylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) THF, hexane, -78 deg C, 0.5 h

2: LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

3: NaBH₃CN, HCl / methanol / 2 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; sodium cyanoborohydride; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1248/cpb.44.1168

Reference yield:

: 121048-68-8
1-(thien-2-yl)propyl isocyanide

: 120656-45-3
1-ethyl-4-(3,4,5-trimethoxyphenyl)-1-(thien-2-yl)-N,N-dimethylbutylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) THF, hexane, -78 deg C, 0.5 h

2: LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

3: NaBH₃CN, HCl / methanol / 2 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; sodium cyanoborohydride; lithium diisopropyl amide; In tetrahydrofuran; methanol;
DOI:10.1248/cpb.44.1168