3-(3,4,5-trimethoxyphenyl)propyl chloride

Base Information

• Chemical Name: 3-(3,4,5-trimethoxyphenyl)propyl chloride
• CAS No.: 110406-98-9
• Molecular Formula: C₁₂H₁₇ClO₃
• Molecular Weight: 244.718
• Mol file: 110406-98-9.mol

Synonyms:3-(3,4,5-trimethoxyphenyl)propyl chloride

Chemical Property of 3-(3,4,5-trimethoxyphenyl)propyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3,4,5-trimethoxyphenyl)propyl chloride

There total 3 articles about 3-(3,4,5-trimethoxyphenyl)propyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3,4,5-trimethoxyphenyl)propan-1-ol (53560-26-2) → 3-(3,4,5-trimethoxyphenyl)propyl chloride (110406-98-9)

Guidance literature:

With thionyl chloride; chloroform; N,N-dimethyl-aniline;

DOI:10.1021/ja01149a091

Reference yield:

3-(3,4,5-trimethoxyphenyl)propanoic acid (25173-72-2) → 3-(3,4,5-trimethoxyphenyl)propyl chloride (110406-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄; diethyl ether

2: N,N-dimethyl-aniline; CHCl₃; SOCl₂

With lithium aluminium tetrahydride; thionyl chloride; diethyl ether; chloroform; N,N-dimethyl-aniline;

DOI:10.1021/ja01149a091

Reference yield:

(E)-3,4,5-trimethoxy-cinnamic acid (20329-98-0,20329-99-1,90-50-6) → 3-(3,4,5-trimethoxyphenyl)propyl chloride (110406-98-9)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium/charcoal; aqueous K₂CO₃ / Hydrogenation

2: LiAlH₄; diethyl ether

3: N,N-dimethyl-aniline; CHCl₃; SOCl₂

With palladium on activated charcoal; lithium aluminium tetrahydride; thionyl chloride; diethyl ether; chloroform; potassium carbonate; N,N-dimethyl-aniline;

DOI:10.1021/ja01149a091

upstream raw materials:

3-(3,4,5-trimethoxyphenyl)propan-1-ol

3-(3,4,5-trimethoxyphenyl)propanoic acid

(E)-3,4,5-trimethoxy-cinnamic acid

Downstream raw materials:

2-chloromethyl-1-(3-chloro-propyl)-3,4,5-trimethoxy-benzene

4-(3,4,5-trimethoxy-phenyl)-butyronitrile

1-ethyl-4-(3,4,5-trimethoxyphenyl)-1-(thien-2-yl)butyl isocyanide

1-ethyl-4-(3,4,5-trimethoxyphenyl)-1-(thien-2-yl)-N-methylbutylamine