BANISTERINE MONOHYDRATE

Base Information

• Chemical Name: BANISTERINE MONOHYDRATE
• CAS No.: 442-51-3
• Molecular Formula: C13H12N2O
• Molecular Weight: 212.251
• Hs Code.: 29339900
• Mol file: 442-51-3.mol

Synonyms:1-Methyl-7-methoxy-b-carboline;7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole;Banisterin;Banisterine;Harmin;Leucoharmine;Telepathin;Telepathine;Yagein;Yageine;

Chemical Property of BANISTERINE MONOHYDRATE

Chemical Property:

• Appearance/Colour: Off-white solid
• Vapor Pressure: 6.42E-07mmHg at 25°C
• Melting Point: 262-264 °C(lit.)
• Refractive Index: 1.706
• Boiling Point: 421.4 °C at 760 mmHg
• PKA: 7.7(at 25℃)
• Flash Point: 139.7 °C
• PSA: 37.91000
• Density: 1.252 g/cm³
• LogP: 3.03310
• Storage Temp.: Refrigerator
• Solubility.: Solubility Slightly soluble in water, ethanol, ether, chloroform
• Water Solubility.: Soluble in DMSO (100 mM), DMF (~1.5 mg/ml), ethanol (~1.5 mg/ml), and PBS (pH 7.2, ~0.25 mg/ml). Insoluble in water.

Purity/Quality:

99% ^*data from raw suppliers

Harmine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 25-36-20/21/22
• Safety Statements: 22-24/25-36/37-26-36

MSDS Files:

Useful:

• Uses: A CNS stimulant isolated from seeds of Peganum harmala L. Zygophyllaceae antiparkinsonian, CNS stimulant central nervous system stimulant

Technology Process of BANISTERINE MONOHYDRATE

There total 29 articles about BANISTERINE MONOHYDRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

7-methoxy-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole hydrochloride (40959-16-8) → harmine (442-51-3)

Guidance literature:

With 5 mol% Pd/C; lithium carbonate; In ethanol; at 150 ℃; for 0.166667h; Sealed tube; Microwave irradiation;

DOI:10.1002/ejoc.201301580

Reference yield: 91.0%

tetrahydroharmine (486-93-1,17019-01-1) → harmine (442-51-3)

Guidance literature:

With sulfuric acid; In 2,2,2-trifluoroethanol; for 30h; Reflux;

DOI:10.1002/anie.201300292

Reference yield: 76.0%

7-methoxy-1-methyl-2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole → harmine (442-51-3)

Guidance literature:

7-methoxy-1-methyl-2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole; In tetrahydrofuran; at -78 ℃; for 2h;

With oxygen; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/chem.201705202

upstream raw materials:

harmaline

glycerol

tetrahydroharmine

nitric acid

Downstream raw materials:

1-(7-methoxy-1-methyl-β-carbolin-9-yl)-1-phenylmethane

Refernces

• 1、 Stolle,Gr?ger. "Studies on the biosynthesis of harmine". . p. 561 - 571. Retrieved 1968.
• 2、 Liu, Wenwu,Liu, Xin,Tian, Liting,Gao, Yaping,Liu, Wenjie,Chen, Huanhua,Jiang, Xiaowen,Xu, Zihua,Ding, Huaiwei,Zhao, Qingchun. "Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease". . . Retrieved 2021/06/21.
• 3、 Shuvalov, Vladislav Yu.,Elisheva, Valeriya А.,Belousova, Anastasiya S.,Arshinov, Evgenii V.,Glyzdinskaya, Larisa V.,Vorontsova, Marina А.,Chernenko, Sergei А.,Fisyuk, Aleksander S.,Sagitullina, Galina P.. "β-Carbolines: synthesis of harmane, harmine alkaloids and their structural analogs by thermolysis of 4-aryl-3-azidopyridines and investigation of their optical properties". . p. 73 - 83. Retrieved 2020/02/18.