Chemical Property of Kaempferol-3-O-rutinoside
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Melting Point:200°C (dec.)
- Boiling Point:941.7°Cat760mmHg
- PKA:6.20±0.40(Predicted)
- Flash Point:312.8°C
- PSA：249.20000
- Density:1.76g/cm3
- LogP:-1.39270
- Storage Temp.:?20°C
- Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- XLogP3:-0.9
- Hydrogen Bond Donor Count:9
- Hydrogen Bond Acceptor Count:15
- Rotatable Bond Count:6
- Exact Mass:594.15847025
- Heavy Atom Count:42
- Complexity:985
- Purity/Quality:
-
≥98% *data from raw suppliers
Kaempferol3-O-β-Rutinoside(Nicotiflorin) *data from reagent suppliers
Safty Information:
- Pictogram(s):
R22:;
- Hazard Codes:Xn
- Statements:
22
- Safety Statements:
22-45-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC=C(C=C5)O)O)O)O)O)O)O
- Isomeric SMILES:C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC=C(C=C5)O)O)O)O)O)O)O
-
Description
Nicotiflorin is a flavonoid that has been found in I. glandulifera and has antioxidant and neuroprotective activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and ABTS radicals with EC50 values of 0.52 and 0.48 mg/ml, respectively, in cell-free assays. Nicotiflorin (1 μM) prevents hydrogen peroxide-induced decreases in tyrosine hydroxylase activity in PC12 cells and cell death in primary rat mesencephalic neurons. It decreases infarct volume by 24.5, 45.8, and 63.2% when administered at doses of 2.5, 5, and 10 mg/kg, respectively, in a rat model of cerebral ischemia-reperfusion injury induced by transient middle central artery occlusion (MCAO).
-
Uses
Kaempferol 3-O-β -Rutinoside is a flavonoid antioxidant compound from Cichorium spinosum L. ecotype plants and also may display anti-diabetic activity. It is a component of many plant species including Helianthemum ruficomum.
