9-AMINO-7-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE

Base Information

• Chemical Name: 9-AMINO-7-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE
• CAS No.: 6115-67-9
• Molecular Formula: C13H13ClN2
• Molecular Weight: 232.7087
• Mol file: 6115-67-9.mol

Synonyms:7-chloro-1,2,3,4-tetrahydro-acridin-9-ylamine;Tacrine Analogue 3;ACRIDINE,1,2,3,4-TETRAHYDRO-9-AMINO-7-CHLORO;9-Amino-7-chloro-1,2,3,4-tetrahydroacridine;

Chemical Property of 9-AMINO-7-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE

Chemical Property:

• Vapor Pressure: 6.33E-08mmHg at 25°C
• Melting Point: 260 °C
• Boiling Point: 439.5°C at 760 mmHg
• PKA: 8.85±0.20(Predicted)
• Flash Point: 219.6°C
• PSA: 39.64000
• Density: 1.308g/cm³
• LogP: 3.27930

Purity/Quality:

NLT 98% ^*data from raw suppliers

7-CHLORO-1,2,3,4-TETRAHYDROACRIDIN-9-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-AMINO-7-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE

There total 7 articles about 9-AMINO-7-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-amino-5-chlorobenzonitrile (5922-60-1) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 7-chloro-1,2,3,4-tetrahydro-acridin-9-ylamine (6115-67-9)

Guidance literature:

With silica gel; toluene-4-sulfonic acid; microwave irradiation;

DOI:10.1002/jhet.5570440305

Reference yield: 69.0%

2-amino-5-chlorobenzonitrile (5922-60-1) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 7-chloro-1,2,3,4-tetrahydro-acridin-9-ylamine (6115-67-9) + 6-chloro-2,2-pentamethylene-1,2-dihydroquinazolin-4(3H)-one (953-76-4)

Guidance literature:

With zinc(II) chloride; In N,N-dimethyl-formamide; for 1.5h; Heating;

DOI:10.1055/s-2007-1000841

Reference yield: 50.0%

4,6-Dichloro-2,3-tetramethylenequinoline (53618-66-9) → 7-chloro-1,2,3,4-tetrahydro-acridin-9-ylamine (6115-67-9)

Guidance literature:

With ammonia; phenol; at 125 - 130 ℃; for 4h;

DOI:10.1021/jm990971t

upstream raw materials:

4,6-Dichloro-2,3-tetramethylenequinoline

cyclohexanone

5-chloroanthranilic acid

2-amino-5-chlorobenzonitrile