Diisopropyl (ethoxycarbonylmethyl)phosphonate

Base Information

• Chemical Name: Diisopropyl (ethoxycarbonylmethyl)phosphonate
• CAS No.: 24074-26-8
• Molecular Formula: C10H21 O5 P
• Molecular Weight: 252.247
• Hs Code.: 2931900090
• European Community (EC) Number: 625-489-3
• DSSTox Substance ID: DTXSID60365187
• Nikkaji Number: J1.478.404G
• Wikidata: Q82149646
• Mol file: 24074-26-8.mol

Synonyms:24074-26-8;Diisopropyl (ethoxycarbonylmethyl)phosphonate;ethyl 2-di(propan-2-yloxy)phosphorylacetate;Ethyl 2-(diisopropoxyphosphoryl)acetate;Ethyl (diisopropyl phosphono)acetate;CBDivE_005331;SCHEMBL2720165;Acetic acid, [bis(1-methylethoxy)phosphinyl]-, ethyl ester;DTXSID60365187;MFCD00075267;Ethyl2-(diisopropoxyphosphoryl)acetate;AKOS003600002;Diisopropyl (carboethoxymethyl)phosphonate;diisopropyl(ethoxycarbonylmethyl)phosphonate;(Diisopropoxyphosphinyl)acetic acid ethyl ester;Ethyl {bis[(propan-2-yl)oxy]phosphoryl}acetate;ethyl 2-[bis(propan-2-yloxy)phosphoryl]acetate;Diisopropyl (ethoxycarbonylmethyl)phosphonate, 95%;J-015340

Chemical Property of Diisopropyl (ethoxycarbonylmethyl)phosphonate

Chemical Property:

• Vapor Pressure: 0.00472mmHg at 25°C
• Refractive Index: n20/D 1.427(lit.)
• Boiling Point: 142-143 °C11 mm Hg(lit.)
• Flash Point: >230 °F
• PSA: 71.64000
• Density: 1.06 g/mL at 25 °C(lit.)
• LogP: 2.59260
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 252.11266076
• Heavy Atom Count: 16
• Complexity: 248

Purity/Quality:

98%Min ^*data from raw suppliers

Diisopropyl (ethoxycarbonylmethyl)phosphonate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CP(=O)(OC(C)C)OC(C)C
• Uses: Reactant for:Preparation of spiroimine ring fragment of spirolides via stereoselective intermolecular Diels-Alder and aza-Wittig cyclizationKatsuki-Sharpless epoxidation reactionPreparation of nine-membered diallylic sulfonamides as chiral building blocksAlpha-phosphono lactams for subsequent Wadsworth-Emmons olefination, and Suzuki coupling reactions to yield diverse pyrrolidinone compoundsSynthesis of galactosylceramide analog that induces Th1-biased responses in human (NKT) cellsStereoselective total synthesis of the ionophore antibiotic zincophorin (M144255)

Technology Process of Diisopropyl (ethoxycarbonylmethyl)phosphonate

There total 4 articles about Diisopropyl (ethoxycarbonylmethyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-chloro-2-ethoxy-vinyl)-phosphonic acid dichloride (42451-44-5) + isopropyl alcohol (67-63-0,8013-70-5) → ethyl (diisopropylphosphoryl)acetate (24074-26-8)

Guidance literature:

In diethyl ether;

Reference yield:

ethyl bromoacetate (105-36-2) → ethyl (diisopropylphosphoryl)acetate (24074-26-8)

Guidance literature:

Reference yield:

triisopropyl phosphite (116-17-6) + chloroacetic acid ethyl ester (105-39-5) → ethyl (diisopropylphosphoryl)acetate (24074-26-8)

Guidance literature:

upstream raw materials:

triisopropyl phosphite

chloroacetic acid ethyl ester

(chloro-isopropoxy-phosphoryl)-acetic acid ethyl ester

isopropyl alcohol

Downstream raw materials:

2-(3-Chloranilino)-2-phenyl-1-ethoxycarbonylethanphosphonsaeurediisopropylester

Farnesol

ethyl (4R,2E)-5-(benzyloxy)-4-methylpent-2-enoate

(R)-ethyl (Z)-5-benzyloxy-4-methyl-2-pentenoate