Chemical Property of Dizocilpine maleate
Chemical Property:
- Appearance/Colour:White Solid
- Vapor Pressure:1.55E-12mmHg at 25°C
- Melting Point:208.5-210°
- Boiling Point:320.3 °C at 760 mmHg
- Flash Point:152.6 °C
- PSA：86.63000
- LogP:3.19110
- Storage Temp.:Store at RT
- Solubility.:DMSO: >20 mg/mL
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:2
- Exact Mass:337.13140809
- Heavy Atom Count:25
- Complexity:432
- Purity/Quality:
-
99%, *data from raw suppliers
(+)-MK-801 hydrogen maleate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
22-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Other Uses -> Biochemical Research
- Canonical SMILES:CC12C3=CC=CC=C3CC(N1)C4=CC=CC=C24.C(=CC(=O)O)C(=O)O
- Isomeric SMILES:C[C@@]12C3=CC=CC=C3C[C@@H](N1)C4=CC=CC=C24.C(=C\C(=O)O)\C(=O)O
-
Uses
(-)-MK-801 MALEATE is probe for NMDA receptors (-)-MK-801 MALEATE acts as an NMDA receptor antagonist. It is selective and potent, but noncompetitive, used in various ischemia treatments. Dizocilpine maleate is used to interact at the NMDA-associated ion channel, preventing Ca2+ flux and blocking NMDA-induced depolarizations. (+)-MK 801 demonstrates potent neuroprotective effects against excitotoxic insult, showing substantial protection against neuron loss produced by NMDA and quinolinic acid introduction.
